lunalovegood's version from 2016-03-06 18:25

Section 1

Question Answer
Name 5 ebola viruses.Zaire, Sudan, Tai Forest, Bundibugyo and Reston
Only affects nonhuman primatesReston ebolavirus
____ stranded ___ virusnegative stranded RNA virus (means they can transfer much much faster)
T/F - Pathogenesis is through direct infection of tissues and through compromising the immune system via bleeding and hemmorhaging.T
T/F - Pathogenesis includes direct infection of tissues, immune dysregulation, hypovolemia and vascular collapse, electrolyte abnormalities, multi-organ failure, septic shock, coagulopathy and disseminated intravascular coagulation (DIC)T
Vomiting blood?hematemesis
Acute onset is ~ ___ days after exposure.8-10 days (range 2-21)
Initial signs and symps?fever, chills, myalgias, malaise, anorexia
After 5 days signs and symps?GI symptoms - nausea, vomiting, watery diarrhea, abdominal pain (other - headache, conjunctivitis, hiccups, rash, chest pain, shortness of breath, confusion, seizures, hemorrhagic symptoms
Hemorrhagic symptoms occur in _________% of cases.18%
5 diseases that cause similar symptoms.malaria, typhoid fever, meningococcemia, Lassa fever and other bacterial infections like pneumonia
Early symptoms progress to...hypovolemic shock, multi-organ failure, hemorrhagic disease, death
Non-fatal cases improve ___ days after symptoms onset.6-11 days
T/F - Fatal disease associated with more severe early symptoms.T
T/F - Fatality rates of 70% have been historically reported in rural Africa. T
High or low? - Platelets? WBCs? AST? ALT? Neutrophils?low, low, high, low, high
T/F - Laboratory findings include thrombocytopenia, leukopenia --> neutrophilia, elevation of AST greater than ALT, electrolyte abnormalities from fluid shifts, PT and PTT prolonged thus coagulation, proteinuria and increased cretinine due to kidney shut down.T
First ___ up then ___ up, as in all infections.IgM, IgG
ELISA is ____ but not ____.specific but not sensitive
Diagnostic tests?RT-PCR and ELISA (for IgM and IgG)
IgM stays up for ___ months. IgG stays up for ___ years.3-6 months, 3-5 years (or lifetime???)
Is there a vaccine?A vaccine called STRIVE looks promising

Section 2

Question Answer
T/F - Been identified in central and south American, Mexico and the Caribbean. Previously been reported in Africa, Southeast Asia and the Pacific Islands.T
____ stranded ___-sense RNA genomesingle stranded positive sense RNA
Two lineages?African and Asian
US version now is the _________ lineage.Asian
Only 1 in _________ people show symptoms.1 in 5
T/F - Symptoms include fever, rash, joint pain, conjunctivitis (red eyes). Others include muscle pain and headache.T
T/F - Zika spread through mosquito bites, infected blood, sexual contact or rarely from mother to child.T
If a mother has Zika virus, should she breastfeed her infant?yes
Virus present longer in blood or semen?semen

Section 3

Question Answer
Family?Rhabdoviridae family (Lyssavirus genus)
Genome encodes 5 proteins?N, P, M, G, L
Incubates in raccoon for...3-12 weeks (20 - 60 days) (no signs of illness)
Infected animal dies within _________ days of becoming sick.7 days
Rabies worst in ___ of the US.middle part
T/F - There is vicious form and dumb form.T (dumb the throat and neck muscles are paralyzed)
Early symptoms?fever headache general malaise
T/F - As the disease progresses- insomnia, anxiety, confusion, slight / partial paralysis, excitation, hallucinations, agitation, hypersalivation, difficulty swallowing and fear of water.T
Best diagnostic?immunofluorescent microscopy or direct fluorescent microscopy (DFA)
Most frequently used diagnostic?DFA (direct fluorescent antibody test)
T/F - Diagnostics for Rabies include DFA, immunofluorescent microscopy, RT-PCR and skin biopsy.T
Solid firm area in peripheral of neuron, resistant to ion exchange, stain darknegri bodies