Wk10 Cell Bio

winniesmith's version from 2017-01-26 13:40

Section 1

Question Answer
what happens at the golgi apparatus (golgi complex)proteins from the ER are processed and sorted for transport to endosomes, lysosomes, the plasma membrane, or secretion.
What is synthesized at the golgi Most glycolipids and sphingomyelin. and complex cell wall polysaccharides in plant cells
What is the golgi composed of flattened membrane-enclosed sacs (cisternae) and associated vesicles.
does the golgi have polarity?proteins from the ER enter at the cis face, usually oriented toward the nucleus and exit from its trans face
What are the 4 regions of the golgi1 cis golgi network, 2 medial golgi stack, 3 trans golgi stack, 4 trans golgi network
What happens at the 1 cis golgi network dorecieves molecules from the ERGIC
what happens at the 3 trans golgi stackmost modifications are done here
what happens at the 4 trans golgi networkthe sorting and distribution center
How do proteins move through the golgiUncertain. Recent studies indicate they are carried in the cisternae, which gradually mature and progressively move through the golgi in the cis to trans direction
what happens to transport vesicles associated with the golgiThey return golgi resident proteins back to earlier golgi compartments for reuse. Evidence for dynamic process; shown by the disappearance of the golgi, if vesicle transport from ER is blocked

Section 2

Question Answer
How are glycoproteins processed in the golgiby modification of N-linked oligosaccharides that were added in the ER.Mannose residues are removed, N-acetylglucosamine, galactose, and sialic acid residues are added.
How are N-linked oligosaccharides of lysosomal proteins modifiedby mannose phosphorylation. They are recognized by a mannose-6phosphate receptor in the trans Golgi network, which transports them to endosomes and on to lysosomes.
What is the specificity of the glycoprotein processThe enzyme, that catalyzes addition of N-acetylglucosamine phosphates.
What are signal patches?structural signals on folded lysosomal proteins recognized by enzymes- in contrast to linear targeting sequencees.
what else takes place in the GolgiO-linked glycosylation (carbohydrates added to side chains of serine and threonine).
How does O-linked glycosylation occurThe serine or threonine is usually linked to N-acetylgalactosamine, to which other sugars are added.
What can be synthesized from ceramide in the golgiglycolipids and sphingomyelin
How is sphingomyelin synthesizedby transfer of a phosphorylcholine group from phosphatidylcholine to ceramide.
what yeilds a variety of glycolipidsaddition of carbohydrates to ceramide