WBC Disorders

sws42792's version from 2015-05-19 14:02

Section 1

Question Answer
CD16Fc receptor marker seen on neutrophils, decreased CD16 in left shift of neutrophils (release of immature cells) from bacterial infections or tissue necrosis
TdT +DNA polymerase, marker for lymphobalsts (not seen in mature lymphocytes), positive in ALL
MPO +Maker for myeloblasts, positive in AML
TdT+, CD10+, CD19+, CD20+B-ALL
t(12;21)B-ALL, good-prognosis, commonly seen in children
t(9;22)Philadelphia chromosome, BCR-ABL fusion protein w/ increased tyrosine kinase activity, B-ALL w/ poor prognosis in adults and CML
TdT+, CD2-CD8+T-ALL - acute lymphoblastic lymphoma (forms a mass in thymus)
t(15;17)APL (type of AML), translocation of retinoic acid receptor (RAR), RAR disruption blocks maturation, promyeloblasts accumulate, treat with ATRA
CD5+, CD20+, CD23+CLL
TRAP+tartrate resistant acid phosphatase, Hairy cell leukemia
CD25+, CD103+Hairy cell leukemia
JAK2 kinase mutationPolycythemia vera, Essential thrombocythemia, Myelofibrosis
Excess PDGFMyelofibrosis
t(14;18)Follicular lymphoma, BCL2 translocates to Ig heavy chain locus, BCL2 inhibits apoptosis, treat w/ rituximab (anti-CD20)
BCL2 overexpression Follicular lymphoma
t(11;14)Mantle cell lymphoma, cyclin D1 gene translocates to Ig heavy chain, promotes G1/S transition
Cyclin D1 overexpressionMantle cell lymphoma
t(8;14)Burkitt lymphoma, c-myc translocation and overexpression, promotes cell growth
c-myc overexpressionBurkitt lymphoma
CD15+, CD30+Hodgkin lymphoma
S-100 and CD1aLangerhans cell histiocytosis

Section 2

Question Answer
Acute leukemia in Down syndrome before age 5Acute megakaryoblastic leukemia (type of AML)
Acute leukemia in Down syndrome after age 5ALL
Auer rodsCrystal aggregates of MPO, seen in AML
Leukemia infiltrating gumsAcute monocytic leukemia (type of AML)
Smudge cellsCLL
Assoc. w/ HTLV-1, lytic bone lesions and hypercalcemia, rashAdult T-cell leukemia/lymphoma (ATLL)
Pautrier's microabscessesATLL and mycosis fungoides, neoplastic mature CD4+ T cells in skin causing rash
Lymphocytes with cerebriform nucleiSezary cells, Sezary syndrome (involvement of blood) in Mycosis fungoides
Can transform to AML or ALLCML (mutation is in a pluripotent stem cell, CD34+)
Blurry vision, headache, flushed face, itching after bathingPolycythemia vera
Excess PDGF causing marrow fibrosisMyelofibrosis
Tear-drop RBCs, nucleated RBCs, and immature granulocytesMyelofibrosis
Lymph node follicular hyperplasia seen in...(B-cell region) seen in rheumatoid arthritis, HIV infection (follicular dendritic cells are CD4+)
Lymph node paracortex hyperplasia seen in...(T-cell region) seen in viral infections (like mononucleosis)
Lymph node sinus histiocyte hyperplasia seen in...lymph nodes draining tissue with cancer
Can progress to Diffuse large B-cell lymphomaFollicular lymphoma, Small lymphocytic lymphoma (aka CLL)
Disruption of lymph node architecture without tingible body macrophagesFollicular lymphoma
Small CD20+ cells, chronic inflammatory statesMarginal zone lymphoma
"starry-sky" appearaneBurkitt lymphoma
Sheets of large CD 20+ cellsDiffuse large B cell lymphoma
Owl-eyed nucleiReed-Sternberg cells of Hodgkin lymphoma
Lacunar cellsNodular sclerosis type of Hodgkin lymphoma
Lymph node divided by bands of sclerosisNodular sclerosis type of Hodgkin lymphoma
Reed-Sternberg cells produce excess IL-5Mixed cellularity Hodgkin lymphoma, abundant eosinophils
Birbeck granules on EMLangerhans cell histiocytosis (tennis racket shaped)
M spike on SPEP with monoclonal IgG or IgAMultiple myeloma or MGUS
M spike on SPEP with monoclonal IgMWaldenstrom macroglobulinemia
Symptoms of Multiple myelomaCRAB: hyperCalcemia, Renal involvement, Anemia, Bone lytic lesions/Back pain

Section 3

Question Answer
t(8;14)Burkitt lymphoma (c-myc activation)
t(9;22)Philadelphia chromosome: CML (BCR-ABL hybrid), also B-ALL
t(11;14)Mantle cell lymphoma (cyclin D1 activation)
t(14;18)Follicular lymphoma (BCL-2 activation)
t(15;17)APL type of AML, translocation of retinoic acid receptor (RAR), responds to ATRA treatment