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Water Soluble Vit Deficiencies

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rvora's version from 2017-01-04 13:55

Section

VitaminPrimary FunctionDeficiency
B1 (thiamine)decarboxylation of alpha-keto acids (carb metabolism), transketolase (HMP shunt), pyruvate dehydrogenaseBeriberi (peripheral neuropathy, heart failure), Wernicke-Korsakoff (confusion, opthalmoplegia, ataxia)
B2 (riboflavin)mitochondrial electron carrier (FAD, FMN)angular cheilosis, corneal vascularization, stomatitis, glossitis, normocytic anemia
B3 (niacin)electron transfer reactions (NAD, NADP)Pellagra (3D's - dermatitis, dementia, diarrhea), peripheral neuropathy, glossitis
B5 (pantothenic acid)coenzyme A and fatty acid synthesisermatitis, enteritis, adrenal insufficiency
B6 (pyridoxine)transamination of amino acidscheilosis, stomatitis, glossitis, convulsions, peripheral neuropathy
B7 (biotin)carboxylation enzyme cofactorcaused by antibiotic use or raw egg whites
B9 (folate)hydromethly, formyl carrier (purine and thymine synthesis)megaloblastic anemia, neural tube defects, nl methylmalonic acid, inc homocysteine
B12 (cobalamin)isomerase and methyltransferase cofactor (DNA and methionine synthesis)megaloblastic anemia, neural deficits, inc homocysteine and methlymalonic acid
C (ascorbic acid)hydroxylation of proline and lysine (collagen synthesis)scurvy (bruising, peridontal dz, hyperkeratotic follicles, poor wound healing)
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