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Vesicular transport

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jambomber's version from 2015-05-02 10:45

Section

Question Answer
What did Pallade establishThat transport in cells is vectorial
What is the vesicular transport hypothesis?Thar proteins are encapsulated within small vesicles that bud of from donors and fuse with acceptor
What did Schekman do?IDed genes ivolved in traffick by complementation cloning
What evidence is there that Sec23/24 +13/31 perform a shared functionReconstitute vescile foratin + cargo selection in birtro
What did S├╝dhof do?Identified proteins which regulate SNARE mediated relaes of NTs ie Synaptotagmin whch controls Ca2+ release
What are interesting questions remaining?Is trafficking constituitive or regulated . how exactly do autophagi vacules form de novo, How is complexity of endosotubular n/w established
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