laracrystalo's version from 2015-05-07 18:32


Question Answer
polyangiitis rheumaticagiant cell (temporal) Arteritis
jaw claudicationgiant cell arteritis
pulseless diseasetakayasu
older than 50giant cell
younger than 50takayasu
branches of carotidgiant cell
left subclavian affectedtakayasu
difference in Sbp between armstakayasu
decreased pulses in armstakayasu
histopathological findings of giant cell and takayasu?intimal thickening with granulomatous inflammation, giant cells, narrowed lumen, internal elastic lamina fragmentation
affects renal arteries but NOT capillaries, arterioles or venulesPAN (so no glomerulonephritis)
inflammatory aneurysms with string of pearls appearancePAN
associated with chronic hep B infectionPAN
spares the lungs!PAN
cause of death is often renal hypertentionPAN
fibrinoid necrosis bc of ag-ab complex deposition and fibrinPAN
autoantibodies to endothelial and smooth muscle cellsKawasaki
predilection for coronary arteriesKawasaki
MI in childrenKawasaki
treatment for kawasaki?IV Ig, aspirin to reduce the rate of CAD!
symptoms of kawasaki?mucocutaneous lymph node syndrome + fever: Conjunctivitis, Rash (erythematous and desquamation), Adenopathy (cervical lymph node enlargement), strawberry tongue, hands and feet
what are the large vessel vasculitides?giant cell arteritis and takayasu
what are the medium vessel vasculitides?PAN, kawasaki
what are the small vessel vasculitides?ANCA associated--Granulomatosis with polyangitis (wegener granulomatosis), Eosinophilic granulomatosis with polyangiitis (Churg strauss syndrome), microscopic polyangiitis. And, immune complex SVV--cryoglobulinemia and cutaneous leucosystoclastic vasculitis
what are the ANCA associated vasculitides?small vessels! Wegener (granulomatosis with polyangitis), Churg strauss (eosinophilic granulomatosis with polyangiitis), or microscopic polyangiitis
which are P ANCA related?Remember, P-ANCA is MPO-ANCA. These are Churg Strauss (eosinophilic granulomatosis) and Microscopic polyangitis
which are C ANCA related?Remember, C-ANCA is PR3-ANCA. This is Wegener granulomatosis (granulomatosis with polyangitis)
which is associated with a triad of symptoms and what is the triad?Wegener granulomatosis with polyangitis. C anca. Necrotizing vasculitis. 1. granulomatous necrotizing inflammation of the lungs 2. vasculitis prominent in respiratory organs, renal disease of necrotizing glomerulonephritis
nodular lesions on lung seen in CXR or grossly?Wegener granulomatosis with polyangitis
necrotizing glomerulonephritis?Wegener granulomatosis with polyangitis and Microscopic Polyangitis (remember, PAN affects kidneys, but not capillaries so NO glomerulonephritis!)t
necrotizing inflammation of the lungs?Wegener granulomatosis with polyangitis
granuloma with abundant eosinophils?Churg Strauss Eosinophilic granulomatosis with polyangitis
associated with asthma and allergic rhinitis?Churg Strauss Eosinophilic granulomatosis with polyangitis
high IgE?Churg Strauss Eosinophilic granulomatosis with polyangitis
NO eosinophils and NO granulomas?Microscopic polyangitis
Pauci-immune associated?Microscopic polyangitis
necrotizing vasculitis?Microscopic polyangitis, wegener granulomatosis with polyangitis
treatment for small vessel vasculitides?steroids!
80% of patients die within 1 yearWegener's granulomatosis with polyangitis
treat with TNF blockersWegener's granulomatosis with polyangitis

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