Uveitis Part 1

ashleyr2's version from 2018-02-22 00:07

Section 1

Question Answer
most common cause of anterior uveitis?idiopathic (50%) followed by HLA-B27
most common cause of acute noninfectious hypopyon iritis?HLA-B27 iritis
what are 4 causes of chronic nongranulaomtous anterior uveitis?JRA, Fuchs' heterochromic iridocyclitis, HSV, HZO
what are 8 causes of infectious granulomatous anterior uveitis?1) syphilis, 2) TB 3) leprosy 4) brucellosis 5) toxoplasmosis 6) P. acnes 7) fungal (cryoptococcus and aspergillus) 8) HIV
what are 5 causes of immune-mediated granulomatous anterior uveitis?1) sarcoidosis 2) VKH syndrome 3) sympathetic ophthalmia 4) lens-induced 5) MS
what 2 cell types are nongranulomatous KPs made out of?lymphocytes and PMNs
what 4 cells types are granulomatous KPs made out of?macrophages, lymphocytes, epitheliod cells, and multinucleated giant cells
what are 4 ddx of diffuse KP?1) fuchs heterochromic iridocyclutis 2) sarcoid 3) syphilis 4) keratouveitis 5) toxoplasmosis
where are koeppe iris nodules located?pupil margin
where are busacca iris nodules located?located on anterior iris surface, occurs only in granulomatous uveitis
where are berlin iris nodules located?located in anterior chamber angle; occurs in granulomatous uveitis
name anterior uveitis a/w hypopyonHLA-B27, foreign body, JRA, Behcets diease, VKH syndrome, malignancy (leukemia, lymphoma, retinoblastoma), toxic (rifabutin)
name 5 ddx for uveitic glaucoma1) HSV 2) HZV 3) Posner-schlossman syndrome 4) fuchs heterochromic iridocyclitis 4) sarcoidosis
child with recurrent or chronic iridocyclitisrule out JRA (ANA positive, RF negative)

Section 2

Question Answer
if you see granulomatous uveitis, what 2 things must you rule out?TB and sarcoidosis
if child has recurrent or chronic iridocyclitisrule out JRA (usually ANA positive, RF negative)
what HLA is a/w JRA?HLA-B8
if you see retinal vasculitis, recurrent aphthous ulcers, and pretibial skin lesionsrule out Behcets disease
how do you work up behcets?skin lesion biopsy, HLA-B51 and HLA-B27
what two HLA are a/w behcetsHLA-B51 and HLA-B27
If you see pars planitis and episodic paresthesisrule out MS, get MRI brain and LP
If you see retinochoroiditis adjacent to pigmented chorioretinal scarrule out toxoplasmosis --> get toxo IgM and IgG
if you have retinal vasculaitis and sinusitisrule out wegeners granulomatosis
if you have choroiditis, exudative RD, and episodic tinnitisrule out Haradas disease and VHK syndrome
if you see an elderly female with vitritisrule out intraocular lymphoma or infection
whats the triad of reiters syndromeconjunctivitis, urethritis, arthritis
what two HLA is a/w psoriatic arthritis?HLA-B17 and HLA-B27

Section 3

Question Answer
Whats the pathology in fuchs heterochromic iridocyclitis?plasma cells in ciliary body
does fuchs have good or poor response to steroids?POOR response to steroids
what are the 2 main complications of fuchs heterochromic iridocyclitis?glaucoma (60%) and PSC cataract (50%)
whats the most common type of intermediate uveitis (90%)pars planitis
what HLA is a/w pars planitis? and what disease is a/w pars planitis?HLA-DR15 and MS
what are snowballs made out of?epitheloid cells and multinucleated giant cells
what are snowbanks made out of?preretinal membrane of fibroglial and vascular elements
what are the most common causes of pars planitis?sarcoidosis, toxoplasmosis, toxocariasis, syphilis, lyme disease, MS