USMLE Female Repro Path

riosju10's version from 2016-06-02 14:34

Section 1

Question Answer
Abruptio placentaepremature detachment of placenta
Abruptio placentaesmoking, cocaine, HTN
Placenta accretadefective decidual layer allows placental attachment to myometrium
Placenta previaattachment of placenta to lower uterine segment
Endometritisinflammation associated with retained products of conception following delivery/miscarriage/abortion or foreign body
Endometritistx- cefoxitin, ticarcillin-clavulanate, ampicillin-sulbactam
Endometriosisnon-neoplastic endometrial glands/stroma in abnormal locations outside the uterus
Endometriosiscyclic bleeding and chocolate cysts
Endometriosismenorrhagia, dysmenorrhea, dyspareunia, infertility, NORMAL sized uterus
Endometriosistx- danazol
Adenomyosisendometrium within the myometrium
Adenomyosismenorrhagia, dysmenorrhea, dyspareunia, infertility, ABNORMAL sized uterus
Adenomyosistx- hysterectomy
PCOSincreased LH, testosterone, estrogen, decreased FSH
Follicular cystdistension of unruptured graafian follicle
Follicular cystmost common ovarian mass in young women
Corpus luteum cysthemorrhage into persistent CL
Theca-lutein cystoften bilateral, multiple
Theca-lutein cystdue to gonadotropin stimulation, associated with choriocarcinoma and moles
Hemorrhagic cystBV rupture in cyst wall
Sarcoma botryoidesgirls less than 4, spindle-shaped cells that are desmin +

Section 2 (benign)

Question Answer
Leiomyomamost common of all tumors in females
Leiomyomabenign SM tumor, estrogen sensitive
Leiomyomawhorled pattern of SM bundles
Leiomyosarcomabulky, irregularly shaped tumor with areas of hemorrhage and necrosis
Dermoid cystmature teratoma, benign
Serous cystadenomabenign, bilateral, fallopian tube-like epithelium
Serous cystadenomaCA-125 for monitoring progression (not screening)
Mucinous cystadenomabenign, multilocular cyst lined by mucous-secreting epithelium
Brenner tumorbenign, unilateral, looks like bladder, pale yellow and appears encapsulated
Brenner tumorcoffee bean nuclei
Meigs' syndromeovarian fibroma, ascites, hydrothorax, pulling sensation in groin

Section 3 (malignant)

Question Answer
DysgerminomahCG, LDH
Dysgerminomamalignant, sheets of uniform cells, fried egg cells
Dysgerminomaassociated with Turner syndrome
Choriocarcinomamalignant, can be in mom or baby
Choriocarcinomachorionic villi NOT present, early hematogenous spread to lungs
Yolk sac tumorAFP
Yolk sac tumoryellow, friable, solid masses
Yolk sac tumorSchiller-duval bodies (look like glomeruli)
Immature teratomaaggressively malignant
Struma ovariiteratoma containing functional thyroid tissue
Serous cystadenocarcinomamalignant, bilateral, Psammoma bodies
Serous cystadenocarcinomaBRCA, HNPCC
Granulosa cell tumorprecocious puberty
Granulosa cell tumorCall-exner bodies
Krukenberg tumorGI malignancy that met to ovaries, mucin-secreting signet cell
Clear cell adenocarcinomaDES