What structure secretes PTH (parathyroid hormone)?
Chief cells of parathyroid
What are the 4 principals functions of PTH?
1)decreases bone resorption of calcium and phosphate 2)increases kidney reabsorption of calcium in distal convoluted tubule 3) decreases reabsorption of phosphate in proximal convoluted tubule 4)increases of 1,25-(OH)2 D3 (calcitriol) production by stimulating kidney 1alpha-hydroxylase
What the letters means in the mnemonic ''PTH''?
Phosphate Trashing Hormone (increase production of M-CSF and RANK-L in osteoblasts, stimulating osteoclasts
What increase PTH secretion?
diminution of serum Ca2+, diminution of serum Mg2+
What decrease PTH secretion?
important diminution of serum Mg2+
What are the common causes of diminution of Mg2+?
diarrhea, aminoglycosides, diuretics and alcohol abuse
Is true to say that PTH leads to increase Ca2+ reabsorption and decrease PO4 3- reabsorption in the kidney?