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U4 Endocrine

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tsdownstate2018's version from 2015-05-05 04:38

Section 1

Question Answer
What two drugs are used to treat prolactinomas?Cabergoline and bromocriptine (dopamine agonists)
Besides transphenoidal surgery, what drug is used to treat acromegaly?Octreotide (bromocriptine can be used in conjunction)
What drug is a GH receptor antagonist?Pegvisomant
What drug can be used to treat central Diabetes Insipidus?Chlorpropamide (increases the release of ADH in partial ADH deficiency)
What drug can be used to treat nephrogenic diabetes insipidus?thiazide diuretics like hydrocholorthiazide.
What drugs are used to treat SIADH?conivaptan (V2 receptor antagonist) or demeclocycline (limits collecting tube response to ADH)
What does Leuprolide treat?A GnRH analog, If given short time it treats infertility by increasing FSH/LH, in the long time high levels of FSH/LH will be depressed by high levels of estrogen and progesteron.
What is Somatotrophin used to to treat?A GH analog, treats cretinism.
What is Desmopressin used to treat?An ADH analog, minimal V1 (arterial constriction) activity, works mostly on V2 (renal collecting tubules).
What drugs can be used to treat hyperthyroidism?Propylthiouracil and Methimazole both thionamides both inhibit organifaction. PTU also inhibits 5'-deiodase.
What drug is associated with hypothyroidismLithium
What drug can cause degradation of dexamethasone during suppression test?Phenytoin
Levothyroxine (t4)Used to treat hypothyroidism
What element can be used to treat hyperthyroidism?Iodide, in large enough doses it reduces thyroid hormone secretion, Wolff-Chaikoff mechanism.
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Section 2

Question Answer
FSHGs
LHGs
ACTHGs
TSHGs
CRHGs
hCGGs
ADH (v2)Gs
MSHGs
PTHGs
CalcitoninGs
GlucagwonGs
SomatostatinGi
GnRHGq
GHRHGq
OxytocinGq
ADH (v1)Gq
TRHGq
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