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dopey's version from 2017-12-07 20:13

STD

Question Answer
SyphilisPCN
GonorrheaCeftriaxone IM + Azithromycin
ChlamydiaAzithromycin
BVMetronidazole
TrichoMetronidazole
Pubic licePremethrin
ScabiesPremethrin
HPVPodofilox
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Travel med

Question Answer
Malaria FalciparumSevere: Parenteral quinidine + doxy/tetra/clindamycin (less: atovaquone-proguanil)
Non-falciparum malariaatovaquone-proguanil (need to eradicate latent hypnozoites with primaquine)
RickettsiaeDoxycycline
Typhoid feverCeftriaxone or injectable 3rd gen cephalo
PlagueStreptomycin IM or Gentamicin IM, cipro or levo
MeloidosisIV ceftazidime or meropenem
StrongyloidiasisIvermectin
LeishmaniasisMiltefosine, stibogluconate (only from CDC), liposomal AMB (off label)
RabiesRIG (Plus 4 injections of rabies vaccine HDCV or PCEC)
ChikungunyaNo specific antiviral agent; NSAIDs and steroids could help but rule out Dengue first
DengueNo specific antiviral agent; Steroids or pox platelet transfusions usually not helpful; avoid NSAID or anticoagulant
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Antiviral / Antifungal Cupo

Question Answer
HSV-1 EncephalitisAcyclovir 10 mg/kg IV q8h
Genital herpesValcyclovir, acyclovir, famciclovir (initial, episodic, recurrence)
Herpes Zoster (Shingles)Valacyclovir 1 g TID x 7 days
CMVGanciclovir; second-line (foscarnet)
InfluenzaTamiflu for high risk patients if started within 48 hours
CocciomycosisFluconazole
CandidaEchinocandin or deescalate to fluconazole if C tropical
AspergillusVoriconazole
CryptococcalAMB with Flucytosine, then step down to fluconazole
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OI

Question Answer
CandidaFluconazole (no ppx)
HerpesAcyclovir (ppx)
PCPBactrim
ToxoplasmosisPyrimethamine then Pyrimethamine + sulfadiazine + leucovorin (CS for swelling, anticonvulsants for sz)
Toxoplasmosis ppxBactrim
Mycobacterium avium complexClarithromycin (or azithromycin) + ethambutol
MAC ppxazithromycin or clarithromycin
PrEPTruvada
PEPTruvada + Raltegravir
PregnantAtazanavir + Ritonavir, darunavir + ritonavir
L&D VL > 400Zidovudine
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HIV ART SE

Question Answer
maravirocBBW for hepatotoxicity with systemic allergic reaction
raltegravirCK elevations, LFT
elvitegravirOsteomalacia (softening of bone), nephrotoxic
dolutegravirinsomnia, HA
atazanavirhyperbilirubemia, PR prolongation, kidney stones, chole stones
darunavirrash, liver toxicity
NNRTI'sRash, SJS, hepatotoxicity, metabolic abnormalities
EFVCNS (neuropsychiatric), dyslipidemia, false + cannabinoid, rash
ETRNausea
RPVDepression, insomnia, headache
zidovudinebone marrow suppression, lipoatrophy
TDF, TAFbone marrow suppression
lamivudine, emtricitabinediscoloration of skin, nail
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HBV SE

Question Answer
interferonhepatotoxicity, blood dycrasias, flu like symptoms, thyroid
entecavirBBW: don't use for HIV and HBV connected person who is not on ART (resistance fro NRTI)
adefovirBBW: nephrotoxicity (SCr q12w)
telbuvidinemyopathy, peripheral neuropathy
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HCV SE

Question Answer
Ribavirin + interferonblood dyscrasia
simepravirrash (photosensitivity), test G1a for NS3 Q80K polymorphism
sofosbuvirdo not use with amiodarone - bradycardia
Harvoniledipasvir solubility decreases as pH increases - don't use with antiacids, H2RA, PPI; amiodarone
daclatasvirConsider testing for RAV
ZepatierConsider testing for RAV
EpclusaHA + fatigue
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Fungal SE

Question Answer
AMBInfusion related effects, mechanism of renal toxicity (decrease RBF - electrolytes)
ketoconazoleadrenal insufficiency, gynecomastia, oligospermia
itraconazoleCHF warning (negative inotropic)
voriconazolevisual disturbances, skin cancer, need renal monitoring due to non linear PK, CYP2C19 (variability)
posaconazolesalvage therapy; mostly used for bone marrow transplant patients
isavuconaziumLFT, infusion related
flu cytosineCBC, needs renal adjustment
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