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Tumor suppressor genes

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lilyo's version from 2016-06-01 21:30

Section

Question Answer
APCcolorectal cancer
BRCA1/BRAC2breast and ovarian cancer (DNA repair protein)
CDKN2Amelanoma, pancreatic cancer (p16, blocks G1 --> S phase)
DCCcolon cancer
DPC4/SMAD4pancreatic cancer
MEN1MEN1
NF1Neurofibromatosis type 1 (Ras GTPase activating protein, neurofibromin)
NF2neurofibromatosis type 2 (Merlin (schwannomin) protein)
PTENbreast cancer, prostate cancer, endometrial cancer
Rbretinoblastoma, osteosarcoma (inhibits E2f, blocks G1 --> S phase)
TP53most human cancers, Li-Fraumeni syndrome (p53, activates p21, blocks G1 --> S phase)
TSC1tuberous sclerosis (Hamartin protein)
TSC2Tuberous sclerosis (Tuberin protein)
VHLvon-Hippel-Lindau disease, renal cell carcinoma (inhibits hypoxia inducible factor 1a)
WT1/WT2Wilms Tumor (nephroblastoma)
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