Create
Learn
Share

TPMT

rename
acorrigan's version from 2017-05-10 21:05

Section

Question Answer
What is the most common mutation associated with TPMT deficiency?*3A in Caucasians, *3C in Asians, Africans, African Americans. *3A is a combo of 3B and 3C alleles which are inherited in cis
What proportion of TPMT deficiency is attributable to *3A in Caucasians?Approximately 75%
Why is *3B thought to be a later mutation event?Because it is never found alone (always with *3C to give *3A), and it is not found in African populations that have not mixed with Caucasian populations
memorize