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Toxicology Table V + W

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hrhodes's version from 2015-10-12 20:51

Section

Question Answer Column 3 Column 4 Column 5 Column 6
Valproate>1g/kg lethal or prolonged comaCNS: Depression, delayed, bone marrow suppression, MOF, hypoglycaemia, high ammonia, cerebral oedema, high Na, low CaBSL, ECG, paracetamol, U+Es, CMP, FBC, ABG, Valproate levelABCD HD if level >1g/kg or >700mg/kg and MOFsAC if early, consider MDAC and WBI
Venlafaxine>3g seizures in 30% >7g CVS effectsCNS - tremor, agitation then seizures, coma, CVS - Arrythmia, hypotension, rhabdoBSL, ECG, para CK, VBGABC-HCO3 arrythmias, D benzos agitation and seizuresAC if 2h >4.5g, serotonin syndrome in combination with other meds
Warfarin>2mg/kg - significant INR rise for 72hrs, <0.5mg/kg not clinically significantBSL, ECG, para, INR, LFTsVit K titrate to INR < 4Charcoal, support
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