Topical Contact Allergens

shevyatiwari's version from 2015-04-22 01:14


Question Answer
DPC, SADBE, DNCB are all topical contact allergensT
The ideal contact allergen is not a topical sensitiserF
The ideal contact allergen should be found widely in the environemntF
The ideal contact allergen should not cause significant adverse effectsT
The idea contact allergen cross-sensitisesF
DNCB is the commonest topical contact allergen usedF - first agent, but was found to be mutagenic in the Ames test
DNCB is not mutagenicF, is
Treatment reduces the CD4:CD8 ratio from 10:1 to 4:1 in AAF, 4:1 to 1:1
DPC increases expression of HLA-A, B, C, DR in the epithelium of lower hair folliclesF, decreases
VEGF may be unregulated in treatment for AAT
In warts, these agents may cause a non specific cell mediated immune response triggering virus infected cell lysis and deathT
DNCB increases the incidence of complement binding wart virus antibodies from 15% to 48%T, suggests a role for host factors
Consider FBP, UEC, LFT pre treatment and every 3-4 monthsT


Question Answer
Mutagenic in the ames testF
It's precursor is a potential mutagen and may contaminate commercial samples T
Light sensitiveT
Photolysis product is not mutagenicT
Teratogenic and causes organ toxicity in the hens egg test and mouse teratogenicity assayF
Stable for < 4 weeks if shielded from lightF, 4 weeks, up to 6 months
Usually dissolved in aqueousF, acetone
Pregnancy test should be done priorT
Concentration to eyebrows should be equal to that on the scalpF, 1/10th
Eyelashes should be routinely treatedF
Fexofenadine hydrochloride may improve efficacyT
Minoxidil may improve efficacyF
Inosine pranobex may improve efficacyF
Adenopathy is an uncommon S/EF, in virtually all patients
Eczema is an uncommon S/EF, quite intense, common, can spread to different sites and become generalised
Fever, chills, fainting and flu like symptoms are uncommon S/ET
Vitiligo is an uncommon S/ET
Dyschromia in confetti and vitiligo are more common in fairer skin individualsF, in darker skin
In the treatment of warts, salicylic acid may be beneficialT
Averse effects in the treatment of warts includes contact dermatitis at distant sites, pigmentation, and severe reactionsT


Question Answer
Not mutagenic in the Ames testT
Should be compounded in absorbent ointmentF, it undergoes 41.4% hydrolysis in absorbent ointment
Should be compounded in acetoneT
Should be compounded in hydrophilic petrolatum or isopropyl alcoholF, is unsuccessful in producing dermatitis
More stable than DPCF
Requries storage in the freezerF, fridge
Castling phenomenon can occur with SADBE as well as DPCT, refers to growth at distance sites
The most common adverse effects are local and distant eczema, local lymphadenopathy and pruritusT
A/E are similar to DPCT
Persistent eczema, benign lymphoplasia, contact allergy are common S/EF, uncommon


Question Answer
Not mutagenicF
Genotoxic by sister chromatid exchanges in fibroblastsT
After topical application, >40% is absorbed systemicallyT

Recent badges