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Topical Calineurin Inhibitors

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shevyatiwari's version from 2015-04-19 06:46

Tacrolimus

Question Answer
A macrolideT
Produces by soil bacterium Streptomycin tsukubaensisT
Similar activity to cyclosporineT
Higher MW than cyclosporineF lower - 804Da, therefore penetrates skin better
Binds to FKBP, promoting NFAT-1 F - blocks NFAT-1, prevents IL2 and blocks T cell activation and proliferation
Has an indirect on neurons through calcineurin - desensitises TRPV1 and calcium currentsF - direct effect
Cat CT
Marked absorption is seen in Netherton's syndromeT
Can cause increased facial flushing secondary to etohT
Can cause rosacea but not acneF - can cause both
Can cause reactivation of HPVT
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Pimecrolimus

Question Answer
A naturally occurring macrolideF - a semi synthetic derivative of ascomycin, a macrolide isolated from Streptomycin hydroscpicus
Possibly reduces NFAT2 activity in follicular keratinocytesT
Effective in alopeciaF
Increases risk of malignancyF
Can cause molluscumT
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