Tissue markers

medmaestro's version from 2015-11-03 05:08


Tissue Marker Diagnosis
Question Answer
1 Estrogen and progesterone receptorsBreast cancer
2 BRST-1/ Anti BCA225 (BCA-225 is a glycoprotein secreted by the T47D breast carcinoma cell line and is recognized by monoclonal antibody BRST-1. Its expression was common in adenocarcinomas of the breast, ovary, and lung but infrequent in adenocarcinomas of the gastrointestinal tract. It is less specific than either GCDFP-15 or mammaglobin for the identification of carcinomas as metastatic from the breast)Breast cancer
3 Gross cystic disease fibrous protein-15Breast cancer
4 Thyroid transcription factor 1Lung and thyroid cancer
5 ThyroglobulinThyroid cancer
6 Chromogranin, synaptophysin, neuron specific enolase,CD56Neuroendocrine cancer
7 CDX-2Gastrointestinal cancer
8 Calretinin, mesothelin Mesothelioma
9 Leukocyte common antigenLymphoma
10 S-100, HMB-45,Tyrosinase,Melan-A Melanoma
11 URO-III, thrombomodulinBladder cancer
12 Αlpha-FetoproteinHepatocellular cancer,Germ cell cancer,Hepatoblastoma
13 β-Human chronic gonadotropinGerm cell cancer
14 Prostate specific antigenProstate cancer
15 CytokeratinCarcinomas
16 WT1,Estrogen receptorMullarian/Ovarian ca
17 RCC,CD 10Renal Cell Carcinoma


Question Answer
CK 7 + CK 20 +Urothelial Tumours,Ovarian Mucinous Adenocarcinoma,Pancreatic Adenocarcinoma,Cholangiocarcinoma (Oval CUP)
CK 7 + CK 20 -Lung Adenocarcinoma,Breast Carcinoma,Thyroid Carcinoma,Endometrial Carcinoma,Cervical Carcinoma,Salivary Gland Carcinoma,Cholangiocarcinoma,Pancreatic Carcinoma
CK 7 – CK 20+Colorectal Carcinoma,Merkel Cell Carcinoma
CK 7 – CK 20-Hepatocellular Carcinoma,Renal Cell Carcinoma,Prostate Carcinoma,Squamous Cell And Small Cell Lung Carcinoma,Head And Neck Carcinoma.