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Things About Drugs I Should Know

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drraythe's version from 2015-06-08 22:47

Drugs I have failed to recognize

DrugWhat it is
AmytriptylineTCA
PhenelzineMAOi
AmoxapineTCA
MexiletineClass IB antiarrhythmic
FlecainideClass IC antiarrhythmic
EncainideClass IC antiarrhythmic
PropafenoneClass IC antiarrhythmic
SotalolClass III antiarrhythmic
IbutiliideClass III antiarrhythmic
BretyliumClass III antiarrythmic
AmlodipineCa Channel Blocker
MilrinonePhosphodiesterase inhibitor (used in heart failure when other rxs have failed)
AmrinonePhosphodiesterase inhibitor
AmilorideK-sparing diuretic
TriamtereneK-sparing diuretic
DipyridamolePhosphodiesterase inhibitor (prevents platelet aggregation)
EpitifibatideBinds GP IIb/IIIa complex
TirofibanBinds GP iib/IIIA complex
Aminocaproic acidInhibitor of plasminogen activation
RosiglitazoneThiazolidinedione (decreases insulin resistance/increases sensitivity)
Chlorpropamide1st generation sulfonurea
Tolbutamide1st generation sulfonurea
Miglitolalpha-glucosidase inhibitor
MethimazoleInhibits thyroid hormone synthesis and peripheral conversion of T4 to T3
ProbenecidIncreases urinary excretion of uric acid
BeclomethasoneInhaled glucocorticoid
FlutamideCompetitive androgen receptor antagonist
ClomiphenePartial agonist at estrogen receptors
DanazolMild agonist at androgen and progesterone receptors (treats endometriosis)
Finasteride5-alpha-reductase inhibitor
ProchlorperazineDopamine antagonist (D2 receptor)
Sulfasalazine5-ASA. Rx for IBS
EtopisideTopoisomerase II inhibitor (chemotherapeutic)
Zileuton5-lipooxygenase inhibitor (preventative treatment of asthma)
DiazoxideK+ channel opener for malignant HTN (can cause hyperglycemia!)
FenoldopamDopamine D1 agonist
PirenzepineMuscarinic antagonist (M1 receptors on ECL and M3 on parietal) used in treatment of peptic ulcers
PropanthelineMuscarinic antagonist (M1 receptors on ECL and M3 on parietal) used in treatment of peptic ulcers
Latanoprost (PGF2alpha)Glaucoma drug, increases outflow of aqueous humor through prostaglandin pathway.
ButorphanolOpioid (partial agonist at mu, agonist at kappa), withdrawal if on full opiods
TramadolWeak opoid agonist, inhibits serotonin and Ne uptake. (Decreases seizure threshold)
PergolidePartial dopamine agonist, ergot alkaloid -- Parkinson's Rx
PramipexoleNon-ergot dopamine agonist
RopiniroleNon-ergot dopamine agonist
EntacoponeCOMT inhibitor (prevents L-dopa degradation in Parkinson's)
TolcaponeCOMT inhibitor (prevents L-dopa degradation in Parkinson's)
BenztropineAntimuscarinic used in Parkinson's rx
MemantineNMDA receptor antagonist (prevents excitotoxicity in Alzheimer's)
DonepezilAChE inhibitor (Alzheimer's)
GalantamineAChE inhibitor (Alzheimer's)
RivastigmineAChE inhibitor (Alzheimer's)
TetrabenazineHuntington's Rx, depletes amines
ClomipramineTCA
BuspironeAnxiolytic (serotonin 5-HT1A receptor partial agonist)
VareniclineNicotine addiction (Guess what, this is Chantix)
SuboxoneNaloxone and buphrenophrine (partial agonist), used to treat heroin addiction
DesipramineTCA, least sedating and lower seizure threshold
NortriptylineTCA to use in eldery to prevent anticholinergic SEs
CitalopramSSRI
Cyproheptadine5-HT2 receptor antagonist used to treat serotonin syndrome
VenlafaxineSNRI (Generalized anxiety disorder)
DuloxetineSNRI (diabetic peripheral neuropathy)
IsocarboxazidMAOi
MaprotilineAtypical antidepressant, blocks NE reuptake
MirtazepineAtypical antidepressant, alpha2 antagonis, potent 5-HT2 and 5-HT3 antagonist
AnastrazoleAromatase inhibitor for postmenopausal women w/ breast cancer
ExemestaneAromatase inhibitor for postmenopasual women w/ breast cancer
DinoprostonePGE2 analog. Induces labor
RitodrineBeta 2 agonist. Reduces premature uterine contractions
TamulosinAlpha-1 antagonist selective for alpha1A,D receptors on prostate. Treats BPH.
TheophyllineMethylxanthine. Inhibits phosphodiesterase (decreases cAMP). Blocks actions of adenosine.
BosentanEndothelin antagonist
GuaifenesinExpectorant. Does not suppress cough reflex.
BenzoateGiven for hyperammonemia
PhenylbutyrateGiven for hyperammonemia
TacrolimusBinds FK-binding protein, inhibits secretion of IL-2
Muromonab-CD3 (OKT3)Monoclonal antibody, binds CD3 of T cells
Sirolimus/rapamycinBinds mTOR, inhibits T-cell proliferation in response to IL-2
Mycophenolate mofetilInhibits de novo guanine synthesis and blocks lymphocyte production
DaclizumabMonoclonal antibody, high affinity for IL-2 receptor on activated T cells
AldesleukinIL-2; used in renal cell carcinoma and metastatic melanoma
FilgrastinG-CSF
SarfrasmostimGM-CSF
OprelvekinIL-11, used for thrombocytopenia
EchothiophateGlaucoma treatment, acetylcholinesterase.
OxybutyrninAntimuscarinic, used to reduce urinary urgency
GlycopyrrolateAntimuscarinic, used to reduce urinary urgency
CisaprideSeratonin receptor agonist used for increasing gastric motility. Causes Torsades.
ProcarbazineAlkylating agent
PramlintideDiabetes drug, decreases glucagon.
ExenatideGLP-1 mimetic (diabetes), increases insulin and decreases glucagon release
DemeclocyclineADH antagonist. Can cause nephrogenic DI, photosensitivity and abnormalities of bone/teeth
TriamcinoloneClucocortocoid
Metyrapone11-beta hydroxylase inhibitor; tests HPA axis, stimulates ACTH secretion
Diphenoxylateopiate antidiarrheal related to meperidine
EnoxaparinLow-molecular weight heparin
LepirudinHirudin derivative, directly inhibit thrombin (heparin alternative in HIT)
BivalirudinHirudin derivative, directly inhibits thrombin (heparin alternative in HIT)
ArgatrobanHirudin derivative, directly inhibits thrombin (heparin alternative in HIT)
EnfuvirtideHIV fusion inhibitor
CladribineAdenosine analog
DacarbazineCell-cycle non-specific methylating agent
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Beta Blocker Selectivity

BlockerSelectivity
PropranololNonselective
TimololNonselective
NadololNonselective
PindololNonselective (partial agonist)
LabetalolNonselective alpha AND beta
AcebutololB1 (partial agonist)
BetaxololB1
EsmololB1 (short acting)
AtenololB1
MetoprololB1
CarvedilolNonselective alpha AND beta
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Antipsychotic classifications

DrugClassification
HaloperidolTraditional high potency
TrifluoperazineTraditional high potency
FluphenazineTraditional high potency
PimozideTraditional high potency
ChlorpromazineTraditional low potency
ThiordiazineTraditional low potency
ClozapineAtypical antipsychotic
RisperidoneAtypical antipsychotic
OlanzapineAtypical antipsychotic (Also used in OCD, anxiety, depression, mania, Tourette's)
QuetiapineAtypical antipsychotic
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Benzodiazpine half-lives

DrugDuration of action
AlprazolamShort
TriazolamShort
OxazepamShort
EstazolamMedium
LorazepamMedium
TemazepamMedium
ChloridazepoxideLong
ClorazepateLong
DiazepamLong
FlurazepamLong
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Histamine receptor blockers (Generations)

DrugGeneration
Diphenhydramine1st
Chlorpheniramine1st
Promethazine1st
Melcizine1st
Dimenhydrinate1st
Fexofenadine2nd
Loratadine2nd
Ceterizine2nd
Desloratadine2nd
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