Therapeutic antibodies and recombinant cytokines

maluwosagashite's version from 2016-06-02 14:24

Section 1

Question Answer
AlemtuzumabCD52--> CLL, MS
BevacizumabVEGF --> Colorectal cancer, renal cell carcinoma
cetuximabEGFR --> Stage 4 colorectal cancer, head and neck cancer
Rituximab CD20 --> B- Zell- Non Hodgkin lymhoma, CLL , rgeumatoid arthritis, ITP
Trastuzumab HER2/ Neu --> breat cancer
Adalimumab, Certolizumab, Infliximabsoluble TNF - alpha --> inflammm. bowel disease, rheumatoid arthritis, ankylosing spondylitis, psoriasis
EculizumabComplement protein C5 --> paroxysmal nocturnal hemoglobinuria
natalizumab alpha 4 - integrin --> MS, Crohn disease
AbciximabPlatelet glycoproteins 2b/ 3a --> antiplatelet agent for prevention of ischemic complications in patients
DenusomabRANKL --> Osteoporosis , inhibits Osteoclasts
Digoxin immune Fabantidote for digoxin overdose
Omalizumab IgE --> allergic asthma
PalivizumabRSV prophylaxis for high risk infants
Ranibizumab. Bevacizumabneovascular age - related macular degeneration

Section 2

Question Answer
AldesleukinIL- 2 --> renal cell carcinoma, metastatic melanoma
Eopoetin alfaErythropoetin --> Anemias ( especially in renal failure)
FilgrastimG- CSF --> Recov. of bone marrow
SargramostimRec. of bone marrow
IFN- alphaHep. B und C,karposisarcom, malignant melanoma
IFN - betaMS
IFN - gammachronic granulomatous disease
Romiplostim, Eltrombopagtrombopoetin rezept. agonist --> Thrombozytopenie
Oprelvekin IL 11 -->Thrombozytopenie

Section 3

Question Answer
Cyclosporinecalcineurin inhibit. --> binds cyclophilin and prevents IL2 transcription , nephrotoxicity!gingival hyperplasm and hirsutism
Tacrolimuscalcineurin inhibit. binds FK506 binding protein ( FKBP) -->prevents IL2 transcription , nephrotoxicity! but no gingival hyperplasia or hirsutism
Sirolimus mTOR inhibit. binds FKBP--> prevents response to IL2, not nephrotoxic.
Daclizumab, BasilizumabBlick IL2 R
Azathioprine Antimetobolite precursor of 6- MP --> blocking nucleotide synthesis
Mycophenolate, mofetilreversibly inhibits IMP dehydrogenase reventing purine synthesis ( assos. with invasisv CMV)
Corticosteroidsinhibit transcription of many cytokines --> supress t and b cell function--> induce apoptosis of T- cells