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The mostly important Interleukins

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wudiwida's version from 2018-09-09 04:43

Section

Question Answer
IL-1proinflammatory protein induction, haematopoesis and Th17 differentiation
IL-2Proliferation of effector T and B cells, Treg development, NK differentiation and proliferation, produced by Th1 cells
IL-4Th2 differentiation, IgE class switching, MHC 2 upregulation, alternate macrophage activation (tissue repair). Produced by Th2
IL-5Myeloid cell differentiation and eosinophil activation against helminths. Produced by Th2
IL-6acute phase protein synthesis in liver and leukocyte trafficking and activation
IL-8Chemoattractant for NK,T cells, basophils, eosinophils and angiogenesis
IL-10Immune suppression by Th2 and Treg
IL-12Th1 cell differentiation and cytotoxicity
IL-13IgG and IgE class switching, parasitic defense by activating eosinophils and mast cells. Produced by Th2
IL-14Proliferation of B cells
IL-17Induction of proinflammatory cytokines, chemokines and neutrophil recruitment by Th17
IL-19Inflammatory response
IL-21Regulation of proliferation, differentiation, apoptosis. Produced by Tfh and Th17
IL-22Pathogen defense, wound healing and tissue recognition
IL-23Stimulates IL-17 production, promotes memory T-cell proliferation
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