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Thalidomide

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shevyatiwari's version from 2015-04-25 06:34

Section

Question Answer
Has two isomeric forms in vivoT
Affected by foodF, little difference
Poorly water solubleT
Undergoes non eyzmyatic hydrolysisT
No hepatic metabolism F - involves CYP2C
Half life of 9 hoursT
Excretion is predominantly renalF, <1% excreted renally
SedativeT - useful for prurigo nodular and actinic prurigo
Inhibits TNFaT
Decreases suppressor T cells > helper T cells F, decreases helper T cells increases suppressor T cells
Reduces PML chemotaxis and phagocytosisT
Anti-angiogenicT
Peak vulnerability first trimesterF - day 21-36
Mild proximal weakness and symmetrical painful paraesthesia is a S/ET
Motor weakness recovers faster than sensoryT
memorize

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