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Tetracyclines2

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shevyatiwari's version from 2015-10-17 08:14

Section

Question Answer
4 fused 6-membered ringsT. TETRA 4 CYCLINES - RINGS
BactericidalF, static
Inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome F, 30S (MACRO bind to 50, tetra bind to 30)
Dose dependent antibiotic effectT
Direct and indirect anti-inflammatory properties linked to their abs activityF - independent to their antibiotic activity
Inhibit production of neutrophil chemoattractants by P acnesT
Inhibit neutrophil migration T
Inhibit granuloma due to protein kinase S inhibitionF, protein kinase C inhibition
Inhibit MMP involved in degradation of only collagen but not elasticF, both collagen and elastic tissue
DOwnregulate cytokines in the acquired immune responseF the innate immune response
Scavengers for ROST
Incyclinidine has no antibiotic effectT
Doxycycline is more phototoxic than minocyclineT
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