Testicular Tumors Presentation

fuckdaveliu's version from 2018-06-03 16:30


Question Answer
Testicular Tumors Arise from germ cells or sex cord-stroma. Present as a frim, painless testicular mass that cannot be transilluminated. Most testicular tumors are malignant germ cells tumors.
Germ Cell TumorsMost common type of testicular tumor(>95% of cases). Usually occur between 15-40 years of age
Seminomas (Germ Cell Tumors) Maliganant tumor comprised of large cells with clear cytoplasm and central nuclei (resemble spermatogonia). forms a homogeneous mass with no hemorrhage or necrosis. Most common testicular tumor, resembles ovarian dysgerminoma
Embryonal carcinoma (Nonesminoma, Germ Cell Tumor)Malignant tumor comprised of immature, primitive cells that may produce glands; forms a hemorrhagic mass with necorsis. Aggressive with early hematogenous spread. Increased AFP or Beta HCG may be present
Yolk sac (endodermal sinus) Malignant tumor that resembles yolk sac elements. Most common testicular tumor in children. Schiller-Duval bodies (glomerulus-like structures) seen on histology. AFP is characteristically elevated.
Choriocarcinoma Malignant Tumor of syncytiotropoblasts and crytotrophoblasts (placenta-like tissue, but villi are absent). Spreads early via blood. Beta-hCG is characteristically high; may lead to hyperthyroidism or gynecomastia( alda-subunit of hCG is similar to that of FSH, LH, and TSH)
Teratoma tumor composed of mature fetal tissue derived from two or three embryonic layers. Malignant in males. AFP or Beta-hCG may be increased
Mixed germ cell tumorsGerm cell tumors are usually mixed. Prognosis is based on the worst component
Leydig cell tumor Tumors that resemble sex cord-stromal tissues of the testicle usually benign. Leydig cell tumor usually produces androgen, causing precocious puberty in children or gynecomastia in adults. Characteristic Reinke crystals may be seen on histology.
Sertoli cell tumorSex cord-stromal tumor, benign. Comprised of tubules and is usually clinically silent.
LymphomaMost common cause of a testicular mass in males >60 years old; often bilateral. Usually of diffuse large B-cell type