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Teratogens

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nibebuhi's version from 2016-03-31 19:36

Section

Question Answer
ACE inhibitorsRenal damage
AlcoholLeading cause of birth defects and MR
Alkylating agentsAbsence of digits, multiple anomalies
AminoglycosidesCN VIII toxicity
CocaineAbnormal fetal development and fetal addiction; placental abruption
DESVaginal clear cell carcinoma
Folate antagonistsNeural tube defects
IodideCongenital goiter or hypothyroidism
LithiumEbstein's anomaly (atrialized right ventricle)
Maternal diabetesCaudal regression syndrome (anal atresia to sirenomelia)
SmokingPreterm labor, placental problems, Intrauterine growth restriction (IUGR), ADHD
TetracyclinesDiscolored teeth
ThalidomideLimb defects ("flipper" limbs)
ValproateInhibition of intestinal folate absorption
Vitamin A excessHigh risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities)
WarfarinBone deformities, fetal hemorrhage, abortion
X-rays, anticonvulsantsMultiple anomalies
memorize
Methimazole: Aplasia Cutis Congenita
Phenytoin: Fetal Hydantoin Syndrome: cleft palate, cardiac defects, Phalaynx/fingernail hypoplasia
Carbamazepine: Facial dysmorphism, developmental delay, cardiac defects, Phalynx/fingernail hypoplasia
Fetal alcohol syndrome mechanism: cells fail to migrate.

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