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Teratogens substance

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ismailalmokyad's version from 2018-01-21 05:04

Section

Question Answer
ACE inhibitorsRenal damage
AlcoholLeading cause of birth defects and mental retardation; fetal alcohol syndrome
Alkylating agentsAbsence of digits, multiple anomalies
AminoglycosidesCN VIII toxicity
Cocaine1-Abnormal fetal development
2-fetal addiction
3-placental abruption
Diethylstilbestrol (DES)Vaginal clear cell adenocarcinoma
Folate antagonistsNeural tube defects
Iodide (lack or excess)-Congenital goiter
-hypothyroidism
LithiumEbstein’s anomaly (atrialized right ventricle)
Maternal diabetesCaudal regression syndrome (anal atresia to sirenomelia
Smoking (nicotine, CO)1-Preterm labor,
2-placental problems,
3-IUGR,
4-ADHD
TetracyclinesDiscolored teeth
ThalidomideLimb defects (“flipper” limbs)
Valproateinhibition of intestinal folate absorption, so (neural tube defect )
Vitamin A (excess)Extremely high risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities)
WarfarinBone deformities, fetal hemorrhage, abortion
X-rays,1-microcephaly
2-mental retardation
anticonvulsants
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