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denniskwinn's version from 2015-04-25 16:12

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Question Answer
SympathoplegicsClonidine, alpha-methyldopa
Clonidine, alpha-methyldopa actionscentrally acting alpha 2 agonists - ↓ central adrenergic outflow
Clonidine, alpha methyldopa clinical usesHTN, especially w/renal disease (no ↓ in blood flow to the kidney)
Nonselective alpha blockersPhenoxybenzamine (irreversible), Phentolamine (reversible)
Phenoxybenzamine, Phentolamine applicationPheo (pb before removing tumor, since high levels of released catecholamines will not be able to overcome blockage)
Phenoxybenzamine, Phentolamine toxicityOrthostatic hypotension, reflex tachycardia
Alpha 1 selective blockersPrazosin, terazosin, doxazosin
Prazosin, trazosin, doxazosin applicationHTN, urinary retention in BPH
Prazosin, trazosin, doxazosin toxicity1st-dose orthostatic hypotension, dizziness, headache
Alpha 2 selective blockersMirtazapine
Mirtazapine toxicitysedation, ↑ serum cholesterol, ↑ appetite
Mirtazapine usedepression
Epinepherine with alpha blockerswitches from alpha dominance to beta response - so normally epi increases BP, but with alpha blocker it decreases BP
Phenylephrine with alpha blockerblocker suppresses action but doesn’t reverse effect because it is pure
Beta blockersAcebutolol, betaxolol, esmolol, atenolol, metoprolol, propranolol, timolol, pindolol
Beta blockers for HTN↓CO, ↓Renin (beta receptor blockade on JGA cells)
Beta blockers for Angina Pectoris↓ HR and contractility resulting in ↓O2 consumption
Beta blockers for MI↓ mortality
Beta blockers for SVT (propanolol, esmolol)↓ AV conduction velocity (class II antiarrhythmics)
Beta blockers for CHFslows progression of chronic failure
Beta blockers for Glaucoma (timolol)↓ secretion of aqueous humor
Beta blocker toxicityImpotence, exacerbation of asthma, bradycardia, AV block, CHF, sedation, sleep alterations, use with caution in diabetics
Nonselective beta blockers(B1 = B2) propanolol, timolol, nadolol, pindolol, labetalol (latter alphabet)
Beta 1 selective antagonistsAcebutol (partial agonist), Betaxolol, Esmolol (short acting), Atenelol, Metoprolol - ABEAM(earlier alphabet + M)
Nonselective alpha and beta antagonistsCarvedilol, Labetalol
Partial beta agonistsPindolol, Acebutolol
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Question Answer
Acetaminophen antidoteN-acetylcysteine -
Salicylates antidoteNaHCO3 (alkalinize urine) dialysis
Amphetamines antidote (basic)NH4CL (acidify urine)
Anticholinesterase inhibitors, organophosphates antidoteAtropine, pralidoxime
Antimuscarinic, anticholinergic agents antidotePhysostigmine salicylate
Beta-blockers antidoteGlucagon
Digitalis antidoteStop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
Iron antidoteDeferoxamine
Lead antidoteCaEDTA, dimercaprol, succimer, penicillamine
Mercury, arsenic, gold antidoteDimercaprol (BAL), succimer
Copper, arsenic, gold antidotePenicillamine
Cyanide antidoteNitrite, hydroxycobalamin, thiosulfate
Methemoglobin antidoteMethylene blue, Vitamin C
Carbon monoxide antidote100% O2, hyperbaric O2
Methanol, ethylene glycol (antifreeze) antidoteEthanol, dialysis, fomepizole
Opioids antidoteNaloxone,naltrexone
Benzodiazepines antidoteFlumazenil
TCAs antidoteNaHCO3 (serum alkalinization)
Heparin antidoteProtamine
Warfarin antidoteVitamin K, FFP
tPA, streptokinase antidoteAminocaproic acid
Theophylline antidoteBeta blocker
Iron poisoning mechanismCell death due to peroxidation of membrane lipids
Iron poisoning symptomsGastric bleeding acutely, Chronic - metabolic acidosis, scarring leading to GI obstruction
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Question Answer
Drugs that cause CV atropine like Side effectsTCAs
Drugs that cause Coronary vasospasmCocaine, Sumatriptan
Drugs that cause cutaneous flushingVANC, vancomycin, Adenosine, Niacin, Ca channel blockers
Drugs that cause dilated cardiomyopathyDoxorubicin (adriamycin), daunorubicin
Drugs that cause Torsades de pointesClass III (sotalol), Class IA (quinidine) antiarrhythmics
Drugs that cause agranulocytosisClozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
Drugs that cause aplastic anemiaChloramphenicol, benzene, NSAIDs, propythiouracil, methimazole
Drugs that cause direct Coombs+ hemolytic anemia Methyldopa
Drugs that cause gray baby syndromechloramphenicol
Drugs that cause Hemolysis in G6PD-deficient patientsIsoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (hemolysis IS PAIN)
Drugs that cause megaloblastic anemiaPhenytoin, Methotrexate, Sulfa Drugs (having a blast with PMS)
Drugs that cause Thrombotic complicationsOCPs
Drugs that cause cough ACE inhibitors (ARBS give no cough)
Drugs that cause pulmonary fibrosisBleomycin, Amiodarone, Busulfan (BlAB)
Drugs that cause acuter cholestatic hepatitisMacrolides
Drugs that cause Focal to massive hepatic necrosisHalothane, Valproic acid, Acetaminophen, Amanita phalloides
Drugs that cause hepatitisINH
Drugs that cause Pseudomembranous colitisClindamycin, ampicillin
Drugs that cause Adrenocortical insufficiencyGlucocorticoid withdrawal (HPA suppression)
Drugs that cause gynecomastiaSpironolactone, Digitalis, Cimetidine, chronic Alcohol uses, estrogens, Ketoconazole (Some Drugs Create Awesome Knockers)
Drugs that cause Hot flashesTamoxifen, Clomiphene
Drugs that cause hypothyroidismLithium, Amiodarone
Drugs that cause phenytoinGinigival hyperplasia
Drugs that cause GoutFurosemide, thiazides
Drugs that cause OsteoperosisCorticosteroids, Heparin
Drugs that cause photosensitivitySulfonamides, Amiodarone, Tetracycline (SAT for a photo)
Drugs that cause Rash (stevens- johnson)Ethosuximide, Lamotrigine, Carbamazepine, Phenobarbital, Phenytoin, Sulfa drugs, Penicillin, Allopurinol
Drugs that cause SLE-like syndromeHydralazine, INH, Procainamide, Phenytoin (it’s not HIPP to have lupus)
Drugs that cause Tendonitis, tendon rupture, cart damageFluoroquinolones
Drugs that cause Fanconi’s syndromeExpired tetracycline
Drugs that cause Interstitial nephritisMethicillin, NSAIDs, Furosemide
Drugs that cause CinchonismQuinidine, quinine
Drugs that cause diabetes insipidisLithium, Demeclocycline
Drugs that cause Parkinson-like syndromeHaloperidol, Chlorpromazine, reserpine, metoclopramide
Drugs that cause SeizuresBupropion, Imipenem/Cilastatin, Isoniazid
Drugs that cause Tardive dyskinesiaAntipsychotics
Cinchonism sxflushed and sweaty skin, ringing of ears, blurred vision, impaired hearing, confusion, reversible high frequency hearing loss, headache, abdominal pain, rashes
Drugs that cause disulfiram like rxnMetronidazole, certain cephalosporins, procarbazine, 1st generation sulfonylureas
Drugs that cause nephrotoxicity/neurotoxicityPolymyxins
Drugs that cause nephrotoxicity/ototoxicityAminoglycosides, vancomycin, loop diuretics, cisplatin
Disulfiram like reactionflushing, tachycardia, drop in blood pressure→dizziness, headache, palpitations, N/V
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Question Answer
P450 inducesQuinidine, Barbiturates, St. John’s wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol use - - Queen Barb Steals Phenphen and Refuses Greasy Carbs Chronically
P450 InhibitorsSulfonamides, Isoniazid, Cimetidine, Ketoconazole, Erythromycin, Grapefruit Juice, Acute alcohol use (I SICK KEG A)
Ethylene glycol toxicityAlcohol dehydrogenase converts to oxalic acid leading to Acidosis and nephrotoxicity
Methanol toxicityAlcohol dehydrogenase converts to Formaldehyde and formic acid leading to severe acidosis and retinal damage
Ethanol toxicityAlcohol dehydrogenase converts to acetaldehyde (blocked Fomepizole) - excess of this leads to N/V, headache, hypotension - - Acetaldehyde dehydrogenase converts acetaldehyde to acetic acid (blocked by disulfiram)
Sulfa drugsCelecoxib, Furosemide, probenecid, thiazides, TMP-SMX, sulfasalazine, sulfonylureas, sumatriptan, acetozolamide, sulfonamide, antibiotics
Sulfa allergy sxfever, pruritic rash, stevens-johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria -
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Question Answer
-afil Erectile dysfunction
-aneInhalational general anesthetic
-azepamBenzodiazepine
-azinePhenothiazine (neuroleptic, antiemetic)
-azole Antifungal
-barbitalBarbiturate
-caineLocal anesthetic
-cillin Penicillin
-cycline Antibiotic,
-etine SSRI
-ipramine TCA
-navir Protease inhibitor
-ololBeta antagonist
-operidol Butyrophenone (neuroleptic)
-oxin Cardiac glycoside (inotropic agent) Digoxin
-phyllineMethylxanthine
-pril ACE inhibitor Captopril
-terolB2 agonist
-tidine H2 antagonist
-triptan5-HT 1B/1D agonists (migraine)
-triptylineTCA
-tropin Pituitary hormone
-zolamBenzodiazepine
-zosinalpha 1 antagonist
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