Step 1 - Micro bug list 4

denniskwinn's version from 2015-04-25 16:08


Question Answer
Yellow fever virus (flavi virus) disease featuresYellow fever: High fever, jaundice, black vomit
Yellow fever virus (flavi virus) identificationEnveloped (+) ssRNA genome, small
Yellow fever virus (flavi virus) target tissueLiver
Yellow fever virus (flavi virus) transmissionBite of Aedes spp, mosquito: tropical South america, africa
Yellow fever virus (flavi virus) prevention/treatmentAttenuated vaccine control vector
Dengue virus( flavi virus) disease featuresDengue fever, dengue hemorrhagic fever, dengue shock syndrome
Dengue virus( flavi virus) identificationEnveloped (+) ssRNA, small
Dengue virus( flavi virus) target tissueVascular endothelium, macrophage, liver
Dengue virus( flavi virus) transmissionAedes spp mosquito
Dengue virus( flavi virus) prevention/treatmentNo antiviral, control vector
West nile or st louis encephalitis (Flavi virus) disease featuresEncephalitis, febrile illness
West nile or st louis encephalitis (Flavi virus) identificationEnveloped (+) ssRNA, small
West nile or st louis encephalitis (Flavi virus) target tissueCNS and brain
West nile or st louis encephalitis (Flavi virus) transmissionCulex spp mosquito
West nile or st louis encephalitis (Flavi virus) prevention/treatmentNo antiviral, control vector
Influenza virus (Orthomyxovirus) disease featuresInfluenza, complications include pneumonia, myositis, and Reye syndrome
Influenza virus (Orthomyxovirus) identificationenveloped segmented (-) ssRNA genome; large, Types A, B, C; ELISA: Hemagglutination; RT-PCR
Influenza virus (Orthomyxovirus) target tissueUpper and lower resp tract
Influenza virus (Orthomyxovirus) transmissionResp droplets, Antigen drift (types A and B) promotes epidemics, antigenic shift promotes pandemics
Influenza virus (Orthomyxovirus) prevention/treatmentKilled and live vaccines, Type A: amantadine or rimatadine, Types A or B: Oseltamivir or zanamivir for prophylaxis and treatment
Measles virus (Paramyxovirus) disease features3Cs+K (cough, conjunctivitis, coryza, Koplik spots); maculopapular rash, Subacute sclerosing panencephalitis (SSPE)
Measles virus (Paramyxovirus) identificationEnveloped (-) ssRNA, large, Single serotype; synctia in infected cells
Measles virus (Paramyxovirus) target tissueLung, skin, CNS
Measles virus (Paramyxovirus) transmissionResp droplets
Measles virus (Paramyxovirus) prevention/treatmentLive attenuated vaccine (childhood MMR)
Mumps virus (paramyxovirus) disease featuresBilateral parotitis; spread to testes (unilateral orchitis) may lead to sterility
Mumps virus (paramyxovirus) identificationenveloped (-) ssRNA, large, Single serotypes, synctia in infected cells, ELISA, hemagglutination inhibition
Mumps virus (paramyxovirus) target tissueParotid glands, ovaries, testes, thyroid gland
Mumps virus (paramyxovirus) transmissionResp droplets
Mumps virus (paramyxovirus) prevention/treatmentLive attenuated vaccine (childhood MMR vaccine)
Parainfluenza virus (Paramyxo) disease featuresCroup (types 1,2) in young children, Atypical pneumonia (type 3) in infants and elderly, Common cold (type 4)
Parainfluenza virus (Paramyxo) identificationenveloped (-) ssRNA, large, Four common serotypes; synctia in infected cells
Parainfluenza virus (Paramyxo) target tissueUpper and lower respiratory tract
Parainfluenza virus (Paramyxo) transmissionRespiratory droplets, nosocomial spread common
Parainfluenza virus (Paramyxo) prevention/treatmentHot moist air for symptoms
Respiratory syncytial virus (RSV) (paramyxo) disease featuresCommon cold, Bronchiolitis and atypical pneumonia (immunocompromised infants)
Respiratory syncytial virus (RSV) (paramyxo) identificationStructure same as above, synctia in infected cells
Respiratory syncytial virus (RSV) (paramyxo) target tissueupper and lower respiratory tracts
Respiratory syncytial virus (RSV) (paramyxo) transmissionResp droplets, direct contact
Respiratory syncytial virus (RSV) (paramyxo) prevention/treatmentAnti-RSV immune globulin, Ribavirin
Coxsackie A virus (paramyxo) disease featuresHand-foot-and-mouth disease and herpangina (young children), Aseptic meningitis with possible skin rash, Hemorrhagic conjunctivitis
Coxsackie A virus (paramyxo) identificationUnenveloped; (+), ssRNA genome, small
Coxsackie A virus (paramyxo) target tissueOral mucosa, skin, CNS
Coxsackie A virus (paramyxo) transmissionFecal-oral; respiratory droplets
Coxsackie A virus (paramyxo) prevention/treatmentPleconaril for serious disease
Coxsacie B virus (paramyxo) disease featuresNeonatal myocarditis and pericarditis
Coxsacie B virus (paramyxo) identificationUnenveloped (+) ssRNA genome, small
Coxsacie B virus (paramyxo) target tissueMuscle, skin
Coxsacie B virus (paramyxo) transmissionFecal-oral, respiratory droplets
Coxsacie B virus (paramyxo) prevention/treatmentPleconaril for serious disease
Hepatitis A virus (paramyxo) disease featuresHepatitis A; abrupt onset, usually mild disease
Hepatitis A virus (paramyxo) identificationUnenveloped (+), ssRNA genome, small
Hepatitis A virus (paramyxo) target tissueLiver
Hepatitis A virus (paramyxo) transmissionFecal-oral (uncooked shellfish)
Hepatitis A virus (paramyxo) prevention/treatmentInactivated vaccine, Immune globulin before or soon after exposure
Poliovirus (paramyxo) disease featuresAseptic meningitis, Paralytic poliomyelitis
Poliovirus (paramyxo) identificationUnenveloped (+) ssRNA, small, isolation from CSF, feces
Poliovirus (paramyxo) target tissueOropharynx, CNS, muscle
Poliovirus (paramyxo) transmissionFecal-oral
Poliovirus (paramyxo) prevention/treatmentSalk vaccine (inactivated injected), Sabin vaccine (attenuated oral)
Rhinovirus (paramyxo) disease featuresCommon cold
Rhinovirus (paramyxo) identificationunenveloped (+) ssRNA, small
Rhinovirus (paramyxo) target tissueNasal mucosa, conjunctiva
Rhinovirus (paramyxo) transmissionresp droplets, Fomites, hand to nose contact
Rhinovirus (paramyxo) prevention/treatmentNo antiviral
Rotavirus (Reovirus) disease featuresGastroenteritis: watery diarrhea, fever, vomiting (most severe in infants and children)
Rotavirus (Reovirus) identificationNonenveloped segmented (+/-) dsRNA genome, midsize, Detection of virions or viral antigens in stools
Rotavirus (Reovirus) target tissueGI tract
Rotavirus (Reovirus) transmissionFecal-Oral
Rotavirus (Reovirus) prevention/treatmentRehydration, Vaccine for infants
HIV (Retrovirus) disease featuresAIDS: marked decrease in T cell count increase in opportunistic infections and neoplasms
HIV (Retrovirus) identificationEnveloped (+) ssRNA genome, midsize, reverse transcriptase in virion, ELISA screening for antibodies, Western blot to confirm: RT-PCR to quantitate viral load
HIV (Retrovirus) target tissueCD4 T lymphocytes, macrophages, neurons
HIV (Retrovirus) transmissionVaginal and anal intercourse, blood transfusion, needle sharing, transplacental blood exposure
HIV (Retrovirus) prevention/treatmentScreening of blood supply, HAART
Humant T cell lymphotropic virus (Retrovirus) disease featuresAcute T cell leukemia, Tropical spastic paraparesis
Humant T cell lymphotropic virus (Retrovirus) identificationEnveloped (+) ssRNA genome, midsize; reverse transcriptase in virion
Humant T cell lymphotropic virus (Retrovirus) target tissueCD4T lymphocytes, neurons
Humant T cell lymphotropic virus (Retrovirus) transmissionVaginal and anal intercourse, needle sharing, transfusion, transplacental blood
Humant T cell lymphotropic virus (Retrovirus) prevention/treatmentNo antiviral
Rabies virus (Rhabdo virus) disease featureslethal encephalitis w/seizures and hydrophobia
Rabies virus (Rhabdo virus) identificationEnveloped (-) ssRNA genome, bullet shaped midsize Negri bodies in infected neurons, RT-PCR; immunofluorescence
Rabies virus (Rhabdo virus) target tissueMuscle and nerve cells
Rabies virus (Rhabdo virus) transmissionZoonotic via bite of infected animal (skins, raccoons) or aerosols (bats)
Rabies virus (Rhabdo virus) prevention/treatmentPet vaccination, Killed rabies vaccine before or soon after human exposure to animal with antirabies immune serum
Rubella virus ( Togavirus) disease featuresswollen glands, rash spreading downward from face, Complication in adults = encephalitis, arthritis, Teratongenic for fetus (esp w/infection in first trimester)
Rubella virus ( Togavirus) identificationEnveloped (+) ssRNA, small, IgM antibodies or fourfold increase in IgG antibodies to confirm recent infection
Rubella virus ( Togavirus) target tissueViremia, lymph nodes, skin, CNS
Rubella virus ( Togavirus) transmissionRespiratory droplets, transplacental
Rubella virus ( Togavirus) prevention/treatmentLive attenuated vaccine (childhood MMR vaccine), Maternal antibodies prevent spread to fetus
Equine encephalitis viruses (WEE,EEE,VEE) disease featuresEncephalitis
Equine encephalitis viruses (WEE,EEE,VEE) identificationEnveloped (+) ssRNA, small
Equine encephalitis viruses (WEE,EEE,VEE) target tissueCNS, brain
Equine encephalitis viruses (WEE,EEE,VEE) transmissionAedes, Culex spp and other mosquitos
Equine encephalitis viruses (WEE,EEE,VEE) prevention/treatmentControl vector
Hepatitis D disease featuresAcute disease- similar to B but more severe, most common cause of fulminant hepatitis
Hepatitis D identificationenveloped (-) ssRNA genome: defective virion; HBsAg in envelope; Serology for delta antigen
Hepatitis D target tissueHepatocytes; can replicate only in cells also infected with hepatitis B virus
Hepatitis D transmissionbody fluids via sexual contact, transfusion, needle stick, breastfeeding
Hepatitis D prevention/treatmentHBsAg subunit vaccine, interferon alpha