lizamariereagan's version from 2015-05-05 22:46


Question Answer
Anti-dsDNA , Anti –smithSLE
Anti-0glutamate decarboxylasetype 1 diabetes mellitus
Anti-hemidesmosomebullous pemphigoid
Antihistonedrug-induced lupus
Anti-jo-1, anti-srp, anti-mi-2polymyositis, dermatomyositis
Antimicrosomal, antithyroglobulinhashimoto thyroiditis


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Antimitochondrialprimary biliary cirrhosis
Antinuclear antibodiesSLE, nonspecific
Anti-scl-70 (anti-DNA topoisomerase I)scleroderma (diffuse)
Anti-smooth muscleautoimmune hepatitis
Anti-SSa, anti – SSB (anti-Ro, anti- Lasjogren syndrome


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Anti-TSH receptorgraves disease
Anti-U1 RNP (ribonucleoprotein)mixed connective tissue disease
c-ANCA (PR3- ANCA)granulomatosis with polyangiitis (WEGner)
Iga antiendomysial, IgA anti-tissue transglutaminaseceliac disease
p-ANCA (MPO-ANCA)microscopic polyangiitis, churg-strauss syndrome
rheumatoid factor (antibody, most commonly IgM, specific to IgG Fc region), anti-CCPrheumatoid arthritis


Question Answer
azathioprine mechantimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking purine synthesis (azathio-PURINE)
uses of azathioprinetransplant rejection prophylaxis, rheumatoid arthritis, IBD, autoimmune conditions
toxicity of azathioprineleukopenia, anemia and thrombocytopenia
what degrades 6-MPxanthine oxidase
what increases the toxicity of azathioprineallopurinol


Question Answer
use of sirolimuskidney transplant and regjection prophylaxis
what do –limus drugs bind?FKBP
main pro about sirolumus?non-nephrotoxic
mech of basiliximabmonoclonal antibody that blocks IL-2R
what do glucocorticoids inhibitNF-KB


Question Answer
what can cause iatrogenic cushing syndrome?glucocorticoids
mech of muromonabmonoclonal antibody ; anti-CD3 receptor activity
use of muromonabredue acute rejection in patients with kidney, heart and liver tranplants
use of epoetin alfa (erythropoietin)anemias (esp in renal failure)
use of thrombopoietinthrombocytopenia


Question Answer
use of oprelvekin (interleukin-11)thrombocytopenia
use of filgrastim (granulocyte CSF)recovery of bone marrow
use of sargramostim (granulocyte –macrophage CSFrecovery of bone marrow
use of aldesleukin (IL-2)renal cell carcinoma, metastatic melanoma
use of IFN-alphachronic hep B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma


Question Answer
use of IFN-betaMS
use of IFN-gammachronic granulomatous disease
what does the mab suffix mean?monoclonal antibody; in name is also type of target (eg bacterial or immune system ) and origin (eg human or mouse)
what does the suffix –cept meanreceptor molecule
what does the suffix –nib meankinase inhibitor


Question Answer
target of alemtuzumabCD52
use of alemtuzumabCLL
target of bevacizumabVEGF
use of bevacizumabcolorectal cancer, renal cell carcinoma
target of cetuximabEGFR
use of cetuximabstage 4 colorectal cancer, head and neck cancer


Question Answer
target of rituximabCD20
use of rituximabB cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP
target of trastuzumabHER2/neu
use of trastuzumabbreast cancer, gastric cancer
target of natalizumabalpha4-integrin
use of natalizumabMS, crohn disease


Question Answer
target of eculizumabcomplement protein c5
use of eculizumabparoxysmal nocturnal hemoglobinuria
target of abciximabplatelet glycoprotein IIb/IIIa receptor (IIB times IIIa –abSIXimab)
use of abciximabanti-platelet agent for prevention of ischemic complication in patients under going percutaneous coronary intervention
target of denosumabRANKL
use of denosumabosteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin)


Question Answer
target of digoxin immune fabdigoxin
use of digoxin immune fabantidote for digoxin toxicity
target of omalizumabIgE
use of omalizumaballergic asthma; prevents IgE binding to FceRI
palivizumab targetRSV F protein
use of palivizumabRSV prophylaxis for high – risk infants
target of ranibizumabVEGF
use of ranibizumabneovascular age-related macular degeneration


Question Answer
what do you find at CT scan L1renal arteries and veins
what do you find at CT scan L4 – L5IVC formed by union of common iliac veins
what do you find at CT scan L1-L2renal arteries joining IVC


Question Answer
Who secretes IL-10regulatory T cells and Th2 cells
Mneumonic for IL-10 and TGF-betaboth aTENuate the immune response
What IL’s are pro-inflammatoryIL-1,4,5,12
What does IL-12 doinduces differentiation of T cells into Th1 cells ; activates NK cells
Who secretes IL-12macrophages and B cells


Question Answer
Function of TNF-alphamediates septic shock; activates endothelium; causes leukocyte recruitment and vascular leak
Function of IFN-gammahas antiviral and antitumor properties; activates NK cells and macrophages to kill virus infected cells ; increases MHC expression and antigen presentation in all cells
What helps macrophages contain a TB infection?IFN-gamma
What is responsible for formation of phagolysosome?IFN- gamma
What contributes to granuloma formation and caseous necrosis?IFN-gamma


Question Answer
Complement that does opsonizationc3b and IgG
Complement that does neutrophil chemotaxisc5a
Complement that does viral neutralizationc1, c2, c3, c4
Complement that does lysis (MAC)c5b-9
Complement that does anaphylactic rxnc3a, c4a, c5a
What synthesizes complement?the liver


Question Answer
What does MAC defend against?Neisseria
What mediates the classic pathway?IgG or IgM (GM makes classic cars)
What mediates the alternative pathway?microbe surface molecules
What mediates the lectin pathway?mannose or other sugars on microbe surface
What are the inhibitors of the complement system that help prevent complement activation on self cells?DAF (decay-accelerating factor DAF aka CD55) and C1 esterase inhibitor


Question Answer
C1 esterase inhibitor deficiency causes whathereditary angioedema (epidodes of painless, non-pitting, well circumscribed edema)
What mediates angioedema?bradykinin, c3a and c5a- by increasing vasodilation and permeability
How are bradykinin and kallikren affected in c1 esterase deficiency?both increased
How is C1 esterase inhibitor deficiency inherited?autosomal dominant
What is contraindicated in C1 esterase inhibitor deficiency?ACE inhibitors
C3 deficiency causes?increases risk of severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions
DAf deficiencycomplement mediated lysis of RBC’s and paroxysmal nocturnal hemoglobinuria


Question Answer
What are interferons alpha and beta ?glycoproteins synthesized by viral infected cells that act locally on uninfected cells, priming them for viral defence by helping to selectively degrade viral nucleic acid and protein
What activates interferons? :viral DNA and RNA
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What is activated when a virus infects a primed cell?RNAase L→ degradation of viral/host mRNA and protein kinase→inhibition of viral/host protein synthesis


Question Answer
What cell surface proteins do T cells have?TCR, CD3 and CD28
What does TCR do?binds antigen-MHC complex
What does CD3 do?associated with TCR for signal transduction
What does CD28 do?binds B7 on APC
What cell surface proteins do helper T cells haveCD4, CD40 ligand


Question Answer
What cell surface proteins to cytotoxic T cells haveCD8
What cell surface proteins do B cells haveIg (binds antigen), CD19, CD20, CD21, CD40, MHC II, B7
What does CD21 doreceptor for EBV
What cell surface proteins do macrophages haveCD14, CD40, MHCII, B7, Fc and C3b


Question Answer
What cell surface proteins do NK cells haveCD16, CD56
What does CD16 dobinds Fc of IgG
What does CD56 dounique marker for NK
What cell surface proteins do hematopoietic stem cells haveCD34


Question Answer
When are people given preformed antibodies (passive immunity)after exposure to tetanus toxin, botulinum toxin, HBV, varicella, or rabies (To Be Healed Very Rapidly)
What response does a live attenuated vaccine induce?a cellular and humoral Response
What is the only live attenuated vaccine given to persons with HIV?MMR
What kind of immunity does a live attenuated vaccine inducestrong, often lifelong
When is a live attenuated vaccine contraindicatedin pregnancy or immune deficiency because it may revert to the virulent form


Question Answer
What are the live attenuated vaccines?MMR, polio (sabin), influenza (intranasal), varicella, yellow fever
What is a pro of inactivated or killed vaccine?it is stable and safer than live vaccines
What is a con of inactivated or killed vaccine?it is weaker and you often need a booster
What are examples of inactivated or killed vaccine?cholera, hep A, polio (salk), influena (injection), rabies (RIP Always )


Question Answer
Anti-Ach receptorMyasthenia gravis
Anti-basement membranegoodpasture syndrome
Anti-cardiolipin, lupus anticoagulantSLE, antiphospholipid syndrome
Anticentromerelimited scleroderma (CREST syndrome)
Anti-desmogleinpemphigus vulgaris
how to remember x-linked immunodeficiences mnemonicMissing WBCs (hyper IgM, Wiscott-aldrick, Brutons agammaglobulinemia, Chronic granulomatous disease and Severe combined immunodeficiency (SCID)