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suzifoho's version from 2016-03-22 09:47

Pathologic RBC forms

PictureCell typeAssociation
Teardrop cellBone marrow infiltration (myelofibrosis)
Target cellHbC
Asplenia
Liver disease Thalassemia
SpherocyteHereditary spherocytosis, Autoimmune hemolysis
Sickle cellSickle cell anemia
Reed-sternbergHodgkins
Ringed sideroblastSideroblastic anemia
Macro -OvalocyteMegaloblastic anemia (also hypersegmented PMNs), BM failure
Howell JollyHyposplenia or asplenia (basophilic remnants found in RBCs
Helmet cell (schistocyte)DIC, TTP/HUS, traumatic hemolysis
Heinz bodiesSeen with alpha thalassemia, G6PD deficiency
-ox of iron leads to denatured Hb
ElliptocyteHereditary elliptocytes
bite cellG6PD deficiency
Basophilic stipplingThalassemias, Anemia of chronic disease
Iron deficiency
Lead poisoning
TAIL
Acanthocyte-Abetalipoproteinemia
-Liver disease
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Cancer drugs

BACD

 

Question Answer
ABleomycin
BVinca alkaloids and taxols
CEtoposide
DAntimetabolites
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Coagulation pathway

CBEADFGHI

 

Question Answer
Hemophilia A is deficiency inFactor 8
Hemophilia B is deficiency inFactor 9
Vit K deficiency lowersfactors 2,7,9,10, proteins C and S
Antithrombin inhibitsThrombin, factor 9a, 10a, 11a, 12a
Antithrombin activated byHeparin
ATissue factor→7→ common = 10→2→Fibrin and 13
B12→11→9→8→common = 10→2→Fibrin and 13
CCollagen, basement membrane, activated platelets
DThromboplastin (tissue factor)
Factor 2 =prothrombin
PT evaluatesExtrinsic ( if this is prolonged and other is ok, that mean that 7 has to be abnormal)
PTT evaluatesIntrinsic (if this is prolonged and other is ok, that means that 12, 11, 9, or 8 are abnormal)
antithrombin III knocks off12,11,7,10,2
EVasodilation, permeability, pain
FKallikrein
GPlasmin
Hbradykinin
Ibradykinin
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heme synth

AFBGHCIDEJ
Question Answer
Adelta-aminolevulinic acid synthase: rate limiting step
Bdelta-aminolevulinic acid dehydratase
CPorphobilinogen deaminase
DUroporphyrinogen decarboxylase
EFerrochelatase
FSideroblastic anemia (x-linked, lead poisoning also causes sideroblastic anemia)
GLead poisoning
HAcute intermittent porphyria
IPorphyria cutanea tarda
JLead poisoning
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mech of antiplatelet

ABCDE

 

Question Answer
AGP Ia (
BGP Ib
CAbciximab
DAspirin
EClopidogrel
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thrombolytics

ABCDE
Question Answer
ABlood activator
BAntiactivators, Aminocaproic acid
CtPA, urokinase
DStreptokinase
EAntistreplase ( preformed complex of streptokinase and plasminogen that is dissociated at the site of fibrin clot to release plasminogen)
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