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Step 1 - HemeOnc Images

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denniskwinn's version from 2015-04-25 16:02

EPO

Yolk Sac, Liver, Spleen, Bone Marrow (~You Like Synthesizing Blood)
Adults = sternum, vertebrae, ribs, pelvis

Pathologic RBC forms

PictureCell type/Association
Teardrop cell; Bone marrow infiltration (myelofibrosis)
Target cell; HbC, Asplenia, Liver disease, Thalassemia - (HALT said the hunter to his target)
Spherocyte; HS, Autoimmune hemolysis
Sickle cell; Sickle cell anemia
Reed-sternberd; Hodgkins
Ringed sideroblast; Sideroblastic anemia
Macro -Ovalocyte; Megaloblastic anemia (also hypersegmented PMNs), BM failure
Howell Jolly; Hyposplenia or asplenia (basophilic remnants found in RBCs
Helmet cell (schistocyte); DIC, TTP/HUS, traumatic hemolysis
Heinz bodies; Seen with alpha thalassemia, G6PD deficiency
Elliptocyte; Hereditary elliptocytes
bite celll; G6PD deficiency
Basophilic stippling; (TAIL) Thalassemias, Anemia of chronic disease, Iron Deficiency, Lead poisoning
Acanthocyte; Liver disease, abetalipoproteinemia
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RBC pathology

Question Answer
acanthocyteliver disease, abetapipoproteinemia
basophilic stipplingthalassemias, anemia of chronic disease, iron deficiency, lead poisoning
bite cellG6PD deficiency
elliptocytehereditary elliptocytosis
macro-ovalocytemegaloblastic anemia, marrow failure
ringed sideroblastssideroblastic anemia
schistocyte (helmet cell)DIC, TTP/HUS, traumatic hemolysis
sickle cellsickle cell anemia
spherocytehereditary spherocytosis, autoimmune hemolysis
teardrop cellbone marrow infiltration (e.g. myelofibrosis) (RBCs shed a tear b/c its been forced out of its home)
target cellHbC disease, asplenia, liver disease, thalassemia
heinz bodiesoxidation of iron from ferrous to ferric form, denatured hemoglobin precipitation, damage to RBC membrane, leads to formation of bite cells (a-thalassemia, G6PD deficiency)
howell-jolly bodiesbasophilic nuclear remnants found in RBCs, seeni n functional hyposplenia or asplenia
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Types of Hb

Question Answer
Hemoglobin Aα2/β2, adult normal hemoglobin
Hemoglobin Fα2/γ 2, fetal, higher O2 affinity
Hemoglobin Sα2/β2 ( β-glu --> val)
Hemoglobin Cα2/β2 ( β-glu --> lys)
Hemoglobin SChetero for S and C, less severe than sickle
Hemoglobin Gower 1zeta2/epsilon3
Hemoglobin bartsγ tetramer, seen in α thalassemia
Hemoglobin Hβ tetramer, seen in α thalassemia
Hgb A2α2/δ2, seen in β thalassemia major
Methemoglobulinreversible oxidation to Fe3+
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Cancer drugs

BACD
Question Answer
ABleomycin
BVinca alkaloids and taxols
CEtoposide
DAntimetabolites
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Coagulation pathway

CBEADFGHI

 

Question Answer
Hemophilia A is deficiency inFactor VIII
Hemophilia B is deficiency inFactor IX
Vit K deficiency lowersfactors II, VII, IX, X, proteins C and S
Antithrombin inhibitsThrombin, factor IXa, Xa, XIa, XIIa
Antithrombin activated byHeparin
ATissue factor→VII→ common = X→II→Fibrin and XIII
BXII→XI→IX→VIII→common = X→II→Fibrin and XIII
CCollagen, basement membrane, activated platelets
DThromboplastin (tissue factor)
Factor II =prothrombin
PT evaluatesExtrinsic ( if this is prolonged and other is ok, that mean that VII has to be abnormal)
PTT evaluatesIntrinsic (if this is prolonged and other is ok, that means that XII, XI, IX or VIII are abnormal)
antithrombin III knocks offXII, XI, VII, X, II
EVasodilation, permeability, pain
FKallikrein
GPlasmin
Hbradykinin
Ibradykinin
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heme synth

AFBGHCIDEJ
Question Answer
Adelta-aminolevulinic acid synthase: rate limiting step
Bdelta-aminolevulinic acid dehydratase
CPorphobilinogen deaminase
DUroporphyrinogen decarboxylase
EFerrochelatase
FSideroblastic anemia (x-linked, lead poisoning also causes sideroblastic anemia)
GLead poisoning
HAcute intermittent porphyria
IPorphyria cutanea tarda
JLead poisoning
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mech of antiplatelet

ABCDE

 

Question Answer
AGP Ia (
BGP Ib
CAbciximab
DAspirin
EClopidogrel
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thrombogenesis

BDCEFAHIGJ
Question Answer
ABernard Soullier syndrome
BClopidogrel, Ticlopidine
CFibrinogen
DVwF, fibrinogen
ETXa2
FGlanzmann's thrombasthenia
GVwF, thromboplastin/kinase (tissue factor), tPA, PGI2)
HThrombomodulin
IVwF
JVwF
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thrombolytics

ABCDE
Question Answer
ABlood activator
BAntiactivators, Aminocaproic acid
CtPA, urokinase
DStreptokinase
EAntistreplase ( preformed complex of streptokinase and plasminogen that is dissociated at the site of fibrin clot to release plasminogen)
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