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Specific chemotherapy for cancers

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medmaestro's version from 2016-01-23 21:11

Section

THERAPY FOR VARIOUS CANCERS
Question Answer
1. Adrenal gland cancerMitotane
2. ALLInduction-Vincristine+Prednisolone+Daunorubicin+Asparaginase+Intrathecal Methotrexate (VAPDIM); Consolidation-Hyyper-CVAD Alternated With Cytarabine +Methotrexate
3. AMLCytarabine +Daunorubicin/Idarubicin
4. Anal cancerradiation+5 FU +Mitomycin C
5.Astrocytoma/Glioblastoma multiformaeTemozolamide
6. Bladder cancergemcitabine +cisplatin
7. Breast CancerENDOCRINE-Tamoxifen(For Pre-Menopausal Women),Aromatase Inhibitor (For Post Menopausal Women ) ;ADJUVANT CHEMOTHERAPY – Doxorubicin+Cyclophosphamide+Docetaxel+/-Transtuzumab
8. Brain tumoursNitrosoureas
9. Carcinoidstreptozocin +5 FU OR Doxorubicin + Cyclophosphamide,5 Fluoro uracil(5 FU),Octreotide
10. Cervical CancerCisplatin + Paclitaxel
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Question Answer
11. Choriocarcinomamethotrexate / dactinomycin
12. CLLFCR Or Fludarabine
13. CMLImatinib
14. Colon cancerFOLFOX-6 +/-Bevacizumab; FOLFIRI +/-Bevacizumab
15. Esophageal CaCisplatin +5 FU
16. Hairy Cell LeukemiaCladribine
17. Head and neck cancerCisplatin + 5FU
18. Hepatocellular CarcinomaSorafenib(Remember Also For Thyroid Ca)
19. Hodgkin DiseaseABVD
20. Hypereosinophilic SyndromesHydroxyureas
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Question Answer
21. InsulinomaInterferon / Streptozocin
22. Kaposi SarcomaLiposomal Doxorubicin / Daunorubicin
23. Kidney CancerSunitinib
24. MacroglobulinemiaChlorambucil or fludarabine
25. Melanomadacarbazine or temozolomide or IL-2
26. Mesotheliomacisplatin + pemetrexed
27. Multiple MyelomaBortezomib +Dexamethasone +Lenalidomide(multiagent chemotherapy) or Melphalan+Prednisone
28. NeuroblastomaCyclophosphamide+Etoposide+Doxorubicin+Cisplatin
29. Non Hodgkin LymphomaCHOP-R
30. Non Small Cell Lung CancerCisplatin + Vinorelbine+/-Bevacizumab
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Question Answer
31. Osteosarcomadoxorubicin/cisplatin/ifosfamide/high dose methotrexate(ANY 2 DRUGS)
32. Ovarian CancerCarboplatin +Paclitaxel
33. Pancreatic cancergemciatabine or Gemcitabine+cisplatin/erlotinib
34. Polycythemia VeraHydroxyurea
35. Prostate cancerGnRH agonist+antiandrogen(Flutamide)
36. Rectal cancerradiotherapy +5FU
37. Refractive TTPVincristine
38. Refractory Cases Of Nephrotic SyndromeCyclophosphamide
39. Sickle Cell Anaemia Or ThalassemiaHydroxyurea
40. Small cell lung cancercisplatin + etoposide
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Question Answer
41. Soft tissue sarcomaMAID (Mesna+Adriamycin+Ifosfamide+ Dacarbazine)
42. Stomach cancerepirubicin +cisplatin+etoposide
43. Testicular cancerBEP Bleomycin+Etoposide+Cisplatin
44. Thyroid cancerI131/Sorafenib
45. Uterine CancerProgestins/Tamoxifen / Aromatase Inhibitors;Cisplatin +Doxorubicin + Paclitaxel
46. Waldenstrom MacroglobulinemiaFCR(FCR-Fludarabine+Cyclophosphamide+Rituximab)
47. Wegener’s GranulomatosisCyclophosphamide
48. Wilm’s tumourVincristine+Dactinomycin after Surgery And Radiotherapy
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ABBREVIATIONS-
Question Answer
Hyper-CVADCyclophosphamide+VinCristine +Adriamycin(Doxorubicin)+Dexamethasone
ABVDAdriamycin+Bleomycin+VinBlastine+Dacarbazine
CHOP-RCyclophosphamide+Hydroxydaunorubicin(Doxorubicin)+Oncovin(Vincristine)+Prednisone+Rituximab
FCRFludarabine+Cyclophosphamide+Rituximab
BEPBleomycin+Etoposide+Cisplatin
FOLFOX-6Folinic Acid(Leucovorin)+5FU+Oxaliplatin
FOLFIRIFolinic Acid+5 FU+Irinotecan
MAIDMesna+Adriamycin+Ifosfamide+ Dacarbazine
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GENE THERAPY

Gene therapy refers to introduction of functional genetic material into target cells to replace or supplement defective genes or to modify target cells so as to achieve therapeutic goals.
APPROACHES IN GENE THERAPYAPPLICATIONS OF GENE THERAPY
Gene ModificationCystic Fibrosis,Severe Combined Immunodeficiency
Gene InsertionGrowth Hormone Deficiency ,Familial Hypercholesterolemia
Gene TransferLesch Nyhan Syndrome,Parkinsonism,Alzheimer’s ,Gaucher’s Disease
Gene DeletionMultiple Sclerosis , DMD,Cancer,HIV
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IMPORTANT SIDE EFFECTS

SIDE EFFECTSDRUG
Pulmonary fibrosisbleomycin,busulphan,cyclophosphamide,melphalan,methotrexate,methysergide,amiodarone,acyclovir,nitrofurantoin
NO Pulmonary fibrosisdoxorubicin,methyldopa
Vomiting / nauseamithramycin,actinomycin D ,dacarbazine,cyclophosphamide,cisplatin
Maximum immunosuppressionmethotrexate
Minimum bone marrow toxicitycisplatin
Maximum alopeciacyclophosphamide,dactinomycin
Skin pigmentationarsenic,busulphan,clofazimine,chlorpromazine,cyclophosphamide,dapsone
DRUG AVOIDED IN CARCINOMA BREAST WITH MI & CCFANTHRACYCLINES(Doxorubicin & Daunorubicin-cardiotoxicity)
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Question Answer
Chemotherapeutic drugs can causenecrosis and apoptosis
M/C side effect of chemotherapy administrationisnausea
Peripheral neuropathy can occur with the use ofVincristine,Cisplatin,Procarbazine
Pulmonary Fibrosis is the MC Complication ofBleomycin
Haemorragic cystitis is caused byCyclophosphamide
The primary target of chemotherapeutic drugs isTumour stem cells
Chemptherapeutic agents work byfirst order kinetics
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Question Answer
Anti folate agent that inhibits the dihydrofolate reductasemethotrexate
Anticancer drug which inhibits mitosisVinca alkaloids
Most common side effect of Vincristineperipheral sensory neuropathy
Most widely used Alkylating agentcyclophosphamide
Enzyme ineffective in solid tumours and used as anti cancer agentL-asparaginase
Most common dermatologic side effect of anticancer drugsAlopecia
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Question Answer
Most nephrotoxic anticancer drugCisplatin
Anti cancer drug causing blue urineMitoxantrone
Anticancer agent causing renal tubular toxicitycisplatin
M/C secondary malignancy due to anti neoplastic agentsAcute NON-Lymphocytic leukemia
Anti invasion agent used to reduce the cellularity of tumour massBatibastat
Used in Hodgkin’s disease & a powerful vesicantMechlorethamine
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