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Smart Polymers to Control Release Rate

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ndifranco94's version from 2015-11-10 17:28

Section

Question Answer
Problems w/ diffusion releasenon-linear, dependent on thickness/polymer charac, Release is too fast, tunability limited to 1-2 orders of magnitude
Affinity-Based Drug Deliverydesign specific affinity b/n drug and device, release is dependent upon kinetics of interaction
When is affinity the rate limiting step?When kinetics are slower than diffusion
Affinity-Based characteristicstunable by chemistry over several orders of magnitude, less dependent on thickness
CyclodextrinHydrophilic exterior (-OH) and hydrophobic interior (-C), can be croslsinked into insoluble polymer
Zone of Inhibition Assayobtain lawn of bacteria, placed drug-loaded disc in lawn and incubate for a day, measure clear region around disc
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