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Skeletal Muscle and Neuromuscular Junction Disorders Causes and Risk Factors

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fuckdaveliu's version from 2018-05-19 09:13

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Question Answer
DermatomyositisInflammatory disorder of the skin and skeletal muscle, unknwon etiology, some cases associated with gastric carcinoma
PolymyositisInflammatory disorder of skeletal muscle
X-Linked Musclar DystrophyDegenerative disorder characterized by muscle wasting and replacemetn of skeletal muscle with adipose tissue. Due to defects of dystrophin gene( dystrophin is important for anchoring the muscle cytoskeleton to the extracellular matrix). Mutations are often spontaneous.
Duchenne musclar dystrophyDeletion of dystrophin gene
Becker musclar dystrophyMutation of dystrophin gene
Myasthenia GravisAutoantibodies against the postsynaptic acetylcholine receptor at the neuromuscular junction. More common in women
Lamber-Eaton SyndromeAntibodies against presynaptic calcium channel of the neuromusclar junction. Arises as a paraneoplastic syndrome, most commonly due to small cell carinoma of the lung. Leads to imparied acetylcholine release.
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