Sir Francis

lunalovegood's version from 2016-03-06 03:33


Question Answer
Is Sir Francis a bioterrorist?sure! Group A
Hosts?diverse animal hosts (zoonotic)
______, rabbit fever, deer feverTularemia
Resistant to...freezing temperatures
Sensitive to...heat and disinfectants
Species that is human pathogen...tularensis (tularemia)
Facultative ____cellular pathogenintracellular


Question Answer
Mortality rate?high
Easily transmitted?yes
Easily transmitted from person to person, but like not really. What do I mean?no cases reported from person to person, needs direct contact with lesion and body fluids, so mosquito bites is the route
Bacteria?Francisella tularensis
Type A?tularensis (terrestrial cycle)
Type B?holarctica (aquatic cycle)
CDC doesn't care about...?mediasiatica, novicida
Terrestrial cycle type?Type A
Aquatic cycle type?Type B
Type A & B. More severe?type A
Spread by ticks in...all USA
Spread by mosquitoes in..Russia, Sweden, Finland
Spread by flies in...Western USA, Russia
Takes ___ colony forming units to infect.10 (highly pathogenic, highly contagious)
Targets ... macrophages (replicates to high #'s intracellulary)
T/F - Francisella tularensis can even infect epithelial cells.T (mechanism unknown)
When was tularemia more prevalent?1950s
About ___ cases of tularemia per year in US.200 (mostly south-central and western), mostly rural, mostly summer
T/F - Modes of infection include handling contaminated animal tissues or fluids, bite of infected deer flies mosquitoes or ticks, direct contact with or ingestion of contaminated water food or soil, or inhalation of infective aerosols.T
Incubation period?3-5 days (range is 1-21 days)
Fatality rate treated?1-3% (pneumonic <10%)
Fatality rate untreated?30-60% pneumonic, 5% ulceroglandular
Most virulent form?ulceroglandular
2 MAJOR clinical manifestationsfever and lymphadenopathy
Clinical diagnosis?history of tick or deerfly bite, exposure to tissue of mammalian host or exposure to contaminated water
High fever, malaise, muscle aches, headache, chills and rigors, sore throat, lymphadenopathy, cutaneous papule --> pustule --> tender indolent ulcer with or without escharulceroglandular tularemia
Abrupt onset fever, chills, headaches, muscle aches, non-productive cough, sore throat, sometimes nausea vomiting and diarrheapneumonic tularemia
Grows on?nope. Very difficult to culture. Doesn't grow on regular agar.
Laboratory diagnosis?elevated serum antibody titers to F. tularensis antigen 40-60 fold > than vaccinated person and with no Hx of tularemia OR detection of F. tularensis in clinical specimen by fluorescent assay
Treatment?vaccine and 14d oral antibiotics
Treatment includes _________ days of oral antibiotics14 days
T/F - Tularemia vaccine is live attenuated and currently under FDA review.T
After Tx, symptoms remain for...2-3 weeks
Dental relation?Can present as a dental abscess


Question Answer
Cutaneous ulcer with regional lymphadenopathyulceroglandular
Regional lymphadenopathy with no ulcerglandular
Conjuctivitis with preauricular lymphadenopathyoculoglandular
Stomatitis, pharyngitis, or tonsillitis and cervical adenopathyoropharyngeal
Intestinal pain, vomiting, diarrheaintestinal (unnatural)
Primary pleuropulmonary diseasepneumonic (unnatural)
Febrile illness w/o early localizing signs and symptomstyphoidal (unnatural)
75-85% of naturally occurring casesulceroglandular
Initial clinical picture - systemic illness with prominent signs of respiratory diseasepneumonic tularemia

Recent badges