Serotonin 5-hydroxytryptamine (5-HT)

martinezdvm's version from 2015-12-06 12:39


Question Answer
What is the other name for serotonin? 5-hydroxytryptamine (5-HT)
Where is 5-HT is present in? platelets, enterocomaffin cells, myenteric plexus of GIT and CNS
Serotonin is synthesized from?dietary tryptophan
Serotonin in the GI does what?GIT - regulates motility.
What does 5-HT do in the CNS?CNS - serotonin acts as neurtansmitter. Regulates gut motiliy, body temp, sleep, aggression, sensory perception, congnition, motor activity, pain, mood, behavior.
Excess serotonin in the CNS will lead to?Excess = CNS stimulation.
Deficiency in serotonin in the CNS will lead to? Deficiency = Depression of CNS
Metabolism of 5 HT? Excretion?MAO- excreted in urine
Describe the synthesis and storage of serotonin in the neurons?Stored in vesicles/secretory granules in the axon terminal. Synthesis takes place here too
How is the action of 5 HT terminated?by neuronal uptake of 5HT into the axon.
SSRI are?drugs that prolong the effects of serotonin
SSRI are used when?used to treat depression & neurological disorders.
Pharmacological effects of 5 HT?Smooth m contraction of GI & Bronchi, increases GI activity & decreases arterial blood P


Question Answer
The only ligand gated serotonin receptor is?5-HT-3
The Gi coupled receptors of serotonin are?5-HT-1 & 5
The Gs coupled receptors of 5-HT are?4,6 & 7
5-HT-2 receptor is coupled w which G protein?Gq- increasing intracellular Ca+2 levels
fastest action is through which receptor?H5-HT-3
which serotonin receptors decrease cAMP levels?5-HT-1 & 5-HT-5 (Gi linked)


Question Answer
Name the SSRI:Citalopram, Sertraline (Zoloft), Fluoxetine (Prozac), venlafaxine (Effexor), Paroxetine, Fluvoxamine, and Bupropin.
SSRI are used for what in pets?treating behavioral problems
Ergots:natural serotonin agonists- used for controlling postpartum hemorrhages and to induce uterine involution
Cisapride used to tx?Serotonin agonist for 5 HT 4: Gastric / intestinal stasis, esophageal reflux, constipation / megacolon in cats.
Meteclopramide used to tx?Serotonin agonist FOR 5 HT 4: vomiting disorders, esophageal reflux, gastric stasis / hypomotility
Serotonin antagonist:Cyproheptadine, Ketanserin, Methysergide, Chlorpromazine / Phenoxybenzamine, Odansetron, Granisetron
Cryptoheptadine:5 HT 1 ANTAGONIST Appetite stimulant in cats, Feline asthma and pruritus, and photic head shaking in horses.
which antagonists block 5-HT-2 receptors?Ketanserin & Methysergide
Methysergide 5 HT 2 ANTAGONIST. GIT. Excess secretion of serotonin = diarhea, abd cramps, edema.
Odansetron & Granisetron5 HT 3 ANTAGONIST Antiemetic - chemotheraphy induced.
5 HT 1 receptor is blocked byCryptoheptadine
5 HT 3 receptor is blocked by? Odansetron & Granisetron

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