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SERMs

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zidazije's version from 2017-04-05 03:59

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Question Answer
Tamoxifen (Soltamox)ER antagonist in breast, 1st line for ER (+) breast cancer, risk of fluid retention and thromboembolism
Ospemifene (Osphena)ER antagonist in breast/uterus, has an increased risk of endometrial cancer (add progestin)
Clomiphene (Clomid)ER Antagonist in all tissues, treatment of infertility in anovulatory women, shuts down (-) feed back loop --> increased LH: ADR = blurred vision
Raloxifene (Evista)ER agonist in bone, ADR of DVT (paradoxical cause it lowers LDL)
Fulvestrant (Faslodex)ER Antagonist in all tissues, effective in breast cancers resistant to Tamoxifen
Bazedoxifene (DuaVee)SERM used in osteoporosis and MHT
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