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Self Care Drugs (I)

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alchemist04's version from 2018-06-20 04:28

Proton Pump Inhibitors

BrandGeneric
NexiumEsomeprazole
PrevacidLansoprazole
Zege-rid (Zegerid)Esomeprazole and Sodium Bicarbonate
PrilosecOmeprazole
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PPI QuestionPPI Answer
PPIs MOA1) Proton pump inhibitors (PPIs) irreversibly block the gastric H,K-ATPase, inhibiting gastric acid secretion. 2) PPIs are acid-activated prodrugs that convert to sulfenic acids or sulfenamides that react covalently with one or more cysteines accessible from the luminal surface of the ATPase. Because of covalent binding, their inhibitory effects last much longer than their plasma half-life. However, the short half-life of the drug in the blood and the requirement for acid activation impair their efficacy in acid suppression, particularly at night.
Use of PPIs1) main action is a pronounced and long-lasting reduction of stomach acid production. 2) the most potent inhibitors of acid secretion available 3) Rx for GERD 4) Healing of peptic ulcers 5) Barrett's esophagus 6) Zollinger-Ellison Syndrome 7)eradication of Helicobacter pylori
Side effects of PPI1) Headache 2) Diarrhea 3) Nausea 4) Vomiting 5) Kidney disease 6) bone fractures 7) infections 8) Vitamin deficiency
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H2 Antagonist

BrandGeneric
TagametCimetidine
PepcidFamotidine
ZantacRanitidine
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H2 antagonist QuestionH2 Antagonist Answer
H2 Antagonist MOAblock the action of histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid.
Use of H2 AntagonistH2 antagonists can be used in the treatment of 1) dyspepsia, 2) peptic ulcers 3) gastroesophageal reflux disease.
Side Effects of H2 AntagonistInfrequent side effect include HYPOTENSION. Rare side effect include 1) headache, 2) tiredness, 3) dizziness, 4) confusion, 5) diarrhea, 6) constipation, 7) rash, 8) overall risk of pneumonia in about 1 in 4 users
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Cimetidine FactsCimetidine Explanations
Cimetidine can cause what in men?1) Gynecomastia 2) Hypersecretory conditions 3) Loss of libido 4) impotence
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Cimetidine DDI QuestionsCimetidine DDI Answers
Cimetidine affects pharmacokinetics of drug through what pathway?cimetidine in particular interferes with some of the body's mechanisms of drug metabolism and elimination through the liver cytochrome P450 (CYP) pathway.
Which enzyme does Cimetidine inhibits?cimetidine is an inhibitor of the P450 enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4.
How does Cimetidine affect Serum Concentrations?By reducing the metabolism of drugs through CPY 450 enzymes, cimetidine may increase their serum concentrations to toxic levels.
What are the drugs affected by Cimetidine? 1) warfarin, 2) theophylline, 3) phenytoin, 4) lidocaine, 5) quinidine, 6) propranolol, 7) labetalol, 8) metoprolol, 9) methadone, 10) tricyclic antidepressants, 11) some benzodiazepines, 12) dihydropyridine calcium channel blockers, 13) sulfonylureas, 14) metronidazole, 15) some recreational drugs such as ethanol and 16) methylenedioxymethamphetamine (MDMA).
Rate from the highest to the lowest effects of these H2 antagonists, Ranitidine, Cimetidine and Famotidine on CYP450 metabolismCimetidine > Ranitidine > Famotidine
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Ranitidine DDI QuestionRanitidine DDI Answer
Which drugs does Ranitidine affects their CPY 450 metabolism?1) Warfarin 2) Theophylline 3) Phenytoin 4) Metoprolol 5) Midazolam
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