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Rifamycins

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shevyatiwari's version from 2015-04-23 08:16

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Question Answer
Well absorbed orallyT
Rifamixin used only for selected GIT infections due to lack of absorptionT
Binds to B-subunit of bacterial DNA dependent RNAT
High level of activity against M kansasii and marinumT
Peak concentrations show inter individual variabilityT
Absorption reduced by 1/3 with foodT
Mostly eliminated by the GIT post enterohepatic recirulationT
Highly liophilicT
Turns body excretions red-orangeT
Hepatotoxicity uncommon unless co-administered with isoniazidT
Increase in Bilirubin is possibleT
Decreased risk of DVTF
Cat XF, C
Excreted in breast milk in low concentationT, 0.05%
Induces multiple CYP isoformsT
Can cause haemorrhagic disease if used in the last few weeks of pregnancyT
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