Create
Learn
Share

Retrovirus

rename
zijimubo1's version from 2016-12-16 01:50

Section 1

Question Answer
What are the 3 basic genes of retroviruses?gag - pol - env
What is the general organization of retrovirus genome?5' - LTR - gag-pol-env- LTR - 3'
What do gag genes encode?structural components - matrix, capsid, nueclocapsid
What do pol genes encode?protease, integrase, reverse transcriptase
What do env genes encode?envelope proteins, reside in lipid bilayer and determine the tropism
List to important Retroviruses.HTLV(human t-cell leukemia virus) and HIV
What are two important co-receptors of HIVCCR5 and CXCR4
List the componets of the HIV envelope proteingp120 and transmembrance gp41
memorize

Section 2

Question Answer
Outsidegp120/gp41
MembraneLipid bilayer and matrix
CoreActin
InsideCapsid
Inner coreNucleocapsid, integrase, RNA, reverse transcriptase
memorize

Section 3

Question Answer
What are the stages of the HIV Life Cycle?1) Entry
2) reverse transcription
3) nuclear import
4) integration
5) transcription/RNA export
6) translation
7) assembly/budding
8) maturation
List the sites for drug targets of HIVfusion, reverse transcriptase, integration, protease
memorize