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Reproductive

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cebidesa's version from 2015-06-06 23:39

Breast Tumors

Benign
TumorCharacteristicsEpidemiology
FibroadenomaSmall, mobile, firm, sharp edges, increases size and tenderness with estrogen<25
Intraductal papillomaSmall, grows in lactiferous ducts, below areola, with serous or bloody nipple discharge. Slight increased risk for carcinomaN/A
Phyllodes tumorLarge bulky mass of connective tissue/cysts. Leaf-like projections. May become malignant6th decade
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Malignant
TumorCharacteristics
DCISFills ductal lumen, arises from ductal hyperplasia. No BM penetration
Invasive ductalFirm, fibrous, rock-hard mass with sharp margins. Small, glandular duct-like cells. Worst, most invasive, and most common.
Invasive lobularOrderly row of cells, often multiple and bilateral
MedullaryFleshy, cellular, lymphatic infiltrate with good prognosis
ComedocarcinomaDuctal, caseous necrosis. (subtype of DCIS)
InflammatoryPeau d'orange (dermal lymphatic invasion)
Paget's diseaseEczematous patches on nipple. Suggests underlying carcinoma
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Ovarian Tumors

TumorCharacteristicsMarkers
DysgerminomaSheets of uniform cellshCG, LDH
ChoriocarcinomaLarge, hyperchromatic syncytiotrophoblastic cells, increased frequency of theca-lutein cystshCG
Yolk sac/Endodermal sinusYellow. Have Schiller-Duval bodies (look like glomeruli)AFP
TeratomaMost frequent benign (Mature). Mature, immature, and struma ovarii (can cause hyperthyroidism)N/A
Serous cystadenomaBilateral, fallopian tube-like epithelium. BenignN/A
Serous cystadenocarcinomaBilateral, fallopian tube-like epithelium. MalignantCA-125
Mucinous cystadenomaIntestine-like tissue. BenignN/A
Mucinous cystadenocarcinomaMalignant. Psedomyxoma peritoneiCA-125
Brenner tumorLooks like bladder. BenignN/A
FibromaMeig's syndrome. Spindle-shaped fibroblastsN/A
Granulosa cell tumorCall-Exner bodies (follicles filled with eosinophilic secretions), abnormal uterine bleeding, precocious puberyIncreased estrogen
Krukenberg tumorMetastasis from stomach, mucin-secreting signet cell adenocarcinoma. BilateralN/A
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Testicular tumors

TumorCharacteristicsMarkers
SeminomaMost common. Painless. Ages 13-15. "Fried egg" appearance. RadiosensitiveN/A
EmbryonalPainful. Glandular/papillary morphology.AFP, hCG
Yolk sac/Endodermal sinusYellow. Schiller-Duval bodiesAFP
ChoriocarcinomaHematogenous mets. Disordered synsytiotrophoblastic and cytotrophoblastic cellshCG
TeratomaMalignantN/A
Leydig cellReinke crystals. Androgen producting. Gynecomastia in men, precocious puberty in boys. Golden brownandrogens
Sertoli cellAndroblastoma from sex cord stromaN/A
Testicular cell lymphomaMost common in old menN/A
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Penile disorders

DiseaseCharacteristicsEpidemiology
Bowen's diseaseCIS. Gray, solitary, crusty plaque (on shaft of penis or scrotum). Can progress to SCC5th decade
Erythroplasia of QueyratCIS. Red, velvety plaques (involving glans). Form of Bowen's.5th decade
Bowenoid papulosisCIS. Multiple papular lesions. Doesn't usually become invasiveYounger age group
SCCN/ACommon in Asia, Africa, and South America. Associated with HPV and lack of circumcision
Peyronie's diseaseBent penis due to acquired fibrous tissue formationN/A
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