Renal Cancers

mbch4kz2's version from 2016-04-16 13:20


Question Answer
Name 5 functions of the kidneyRemove waste from the blood, control fluid and electrolytes, regulate acid-base concentration, produce hormones (vitamin D and erythropoietin) and regulate BP
What is the most common renal cell type carcinoma?Clear cell (75%)
Name 5 risk factorsSmoking (most established), obesity, hypertension, renal transplantation, dialysis, pelvic radiation
Name a syndrome associated with clear cell variant of RCCVon Hippel Lindau (VHL) syndrome
What is VHL syndrome?Up to 30% of VHL patients develop RVV, patients have germile inactivation of one VHL allele, a second loss-of-function is an early initiating event for VHL cancer (VHL gene products act as tumour suppressors)
Name 5 symptomsOften asymptomatic (50% of RCCs diagnosed incidentally), haematuria, flank pain, mass or lump in the abdomen, fatigue, weight loss, fever, loss of appetite, oedema (fluid retention), anaemia high PH
Where can cancer spread to?Surrounding fat, adrenal gland, lymph nodes, renal vein and IVC, nearby organs- liver, lung, bone or brain
Why would a FBC be useful?May be anaemia of chronic disease and erythrocytosis from excessive erythropoietin production
What finding is a poor diagnostic finding from testingHigh LDH