Renal Cancer

theyak89's version from 2016-06-02 18:12


Question Answer
Originates from proximal tubule cells. Polygonal clear cells filled with lipids and carbs. 50-70 yo.Renal Cell Carcinoma
Increase incidence with smoking and obesity. 50-70 year old. Clear cellsRenal Cell Carcinoma
Hematuria, palpable mass, Secondary polycythemia, flank pain, fever, weight loss. Invades IVC anda spreads to lung and boneRenal Cell carcinoma
Associated with Chromosome 3 of VHL syndrome. Silent cancer. Renal Cell carcinoma
Paraneoplastic syndromes- Ecotpic EPO, ACTH, PTHrPRenal Cell carcinoma
Benign epithelia cell tumor. Well circumscribed mass with central scar. Renal oncocytoma
Large eosinophilic cells with abundant mitochondria without perinuclear clearing. Painless hematuria, flank pain, abd massRenal oncocytoma
Most common renal malignancy of early childhoodWilms
Contains embryonic glmoerular structures. Huge palpable flank mass or hematuriaWilms
Loss of function mutations on tumor suppressor genes WT1 or WT2 on chromosome 11Wilms
Associated with aniridia, genitourinary malformation, mental retardationWilms- WAGR Syndrome
Most common tumor of urinary tract synstem (calyces, plevis, ureters, bladder)Transitional cell carcinoma
Painless hematuria (no casts). Asscoiated with Phenacetin, Smoking, Aniline dyes, CyclophosphamideTransitional Cell Carcinoma
Papillary growth lined by transitional epithelium with mild nuclear atypiaTransitional Cell Carcinoma
Chronic irritation of bladder causing squamous metaplasiaSqaumous cell cardinoma of bladder
Risk with Schistosoma haematobium (Middle East), chronic cystitis, smoking, chronic stones. Painless hematuria presentationSquamous cell carcinoma of bladder