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Rate limiting enzymes

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lailay's version from 2015-10-19 01:15

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Rate limiting enzyme of: GlycolysisPhosphofructokinase-1 (PFK-1)
Rate limiting enzyme of: GluconeogenesisFructose-1,6-bisphosphatase
Rate limiting enzyme of: TCA cycleIsocitrate dehydrogenase
Rate limiting enzyme of: GlycogenesisGlycogen synthase
Rate limiting enzyme of: GlycogenolysisGlycogen phosphorylase
Rate limiting enzyme of: HMP shuntGlucose-6-phosphate dehydrogenase (G6PD)
Rate limiting enzyme of: De novo pyrimidine synthesisCarbamoyl phosphate synthetase II
Rate limiting enzyme of: De novo purine synthesisGlutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
Rate limiting enzyme of: Urea cycleCarbamoyl phosphate synthetase I
Rate limiting enzyme of: Fatty acid synthesisAcetyl-CoA carboxylase (ACC)
Rate limiting enzyme of: Fatty acid oxidationCarnitine acyltransferase I
Rate limiting enzyme of: KetogenesisHMG-CoA synthase
Rate limiting enzyme of: Cholesterol synthesisHMG-CoA reductase
Positive regulators of: Phosphofructokinase-1 (PFK-1)AMP 􏰇, fructose-2,6-bisphosphate 􏰇
Positive regulators of: Fructose-1,6-bisphosphataseATP 􏰇, acetyl-CoA 􏰇
Positive regulators of: Isocitrate dehydrogenaseADP 􏰇
Positive regulators of: Glycogen synthaseGlucose-6-phosphate 􏰇, insulin 􏰇, cortisol 􏰇
Positive regulators of: Glycogen phosphorylaseEpinephrine 􏰇, glucagon 􏰇, AMP 􏰇
Positive regulators of: Glucose-6-phosphate dehydrogenase (G6PD)NADP+ 􏰇
Positive regulators of: Carbamoyl phosphate synthetase IInone
Positive regulators of: Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferasenone
Positive regulators of: Carbamoyl phosphate synthetase IN-acetylglutamate 􏰇
Positive regulators of: Acetyl-CoA carboxylase (ACC)Insulin 􏰇, citrate 􏰇
Positive regulators of: Carnitine acyltransferase Inone
Positive regulators of: HMG-CoA synthasenone
Positive regulators of: HMG-CoA reductaseInsulin 􏰇, thyroxine 􏰇
Negative regulators of Phosphofructokinase-1 (PFK-1)ATP 􏰈, citrate 􏰈
Negative regulators of Fructose-1,6-bisphosphataseAMP 􏰈, fructose-2,6-bisphosphate 􏰈
Negative regulators of Isocitrate dehydrogenaseATP 􏰈, NADH􏰈
Negative regulators of Glycogen synthaseEpinephrine 􏰈, glucagon 􏰈
Negative regulators of Glycogen phosphorylaseGlucose-6-phosphate 􏰈, insulin 􏰈, ATP 􏰈
Negative regulators of Glucose-6-phosphate dehydrogenaseNADPH 􏰈
Negative regulators of Carbamoyl phosphate synthetase IInone
Negative regulators of Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferaseAMP 􏰈, inosine monophosphate (IMP) 􏰈, GMP 􏰈
Negative regulators of Carbamoyl phosphate synthetase Inone
Negative regulators of Acetyl-CoA carboxylase (ACC)Glucagon 􏰈, palmitoyl-CoA 􏰈
Negative regulators of Carnitine acyltransferase IMalonyl-CoA 􏰈
Negative regulators of HMG-CoA synthasenothing
Negative regulators of HMG-CoA reductaseGlucagon 􏰈, cholesterol 􏰈
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