alkathryn's version from 2016-11-26 18:33


Question Answer
Rphx therapy issystemic but selective
Uses ____ sourcesunsealed
Ideal rphx isselective to tumor site with minimal uptake by or rapid clearance from normal tissue
Effects depend upontotal radiation dose and tissue's sensitivity to radiation
Imaged therapiesI-131 and Samarium, beta/gamma

I-131 Sodium Iodide

Question Answer
Production methodreactor
Hyperthyroidism dose10-30 mCi capsule or liquid
Metastatic thyroid cancer dose100-150 mCi
Radiation dose to thyroid800-1000 rads/mCi
Therapeutic dose is given toablate part of the gland
I-131 israpidlly absorbed
How much is absorbed in 60 mins~90%
Maximum effect occurs at2-4 months
Side effects of txsore throat, mild dysphagia, thyroid storm (rare)
Collimator for uptake probeflat field
Collimator for uptake probeflat field
Collimator for uptake probeflat field
Whole body scan dose s/p surgery2-10 mCi
Thyroid cancer typically treated bytotal thyroidectomy
Dose for metastisis100-150 mCi (low as 30, high as 250)
Whole body imaging post-tx performed5-7 days after
Whole body imaging post-tx is abaseline to compare later on
Radiation safety considerationsbioassay, pt instructions, contamination control, written directive

I-131 Bexxar

Question Answer
Used to treatNHL
NHL isfollicular lymph and large B-cell lymph (very aggressive)
Bexxar akaTositumomab
Potential forHAMA response
Rphx is keptrefrigerated
Procedure takes about7-14 days as an outpatient
____% of lymphoid neoplasms are of B-cell origin80-85%
The most common form of lymphoma isFollicular NHL
All lymphoid neoplasms are derived froma single transformed cell (monoclonal)


Question Answer
Therapeutic treatment forNHL and HCC
Y-90 Zevalin forNHL
Y-90 ThereSpheres/SirSpheres forliver mets
Half life2.7 days
Produced byreactor
Zevalin indicated forpets with relapsed refactor low-grade follicular or transformed B-cell NHL
Zevalin potential forHAMA
Zevalin targets theCD20 antigen on surface of B-cells
Zevalin dose0.04 mCi/kg up to 32 mCi over 10 mins
Zevalin followsIn-111 zevalin imaging to confirm proper distribution
Total body rads Zevalin1.85 rads/mCi
Zevalin most sensitive forstem cells or blood
Injection throughfemoral artery
MAA planning first requireshepatic angiogram
MAA planning comparesliver particles to shunted lung particles
MAA planning dose4 mCi


Question Answer
Production methodreactor
Half-life14.3 days
Sodium phosphate forpainful bone mets AND polycythemia vera
Polyvythemia vera is ablood disorder
Sodium phosphate PVC dose4 - 5 mCi
Sodium phosphate bone met dose7 mCi
Chromic phosphate is formalignant effusion, pertioneal pleual or pericardial
Chromic phosphate injectedintracavitarily