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Public Health Wk 7 Lect. 7 part 3

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alchemist04's version from 2016-05-25 14:42

Section

Question Answer
What are the US surgeon General Report on Nicotine Addiction (1)(1) Cigarettes and other forms of tobacco are addicting
What are the US surgeon General Report on Nicotine Addiction (2)(2) Nicotine is the drug in tobacco that causes addiction
What are the US surgeon General Report on Nicotine Addiction (3)(3) The pharmacologic and behavioral processes that determine addiction to drugs such as heroine and cocaine
True or false? Nicotine is a DRUG?True, nicotine is a drug that causes addiction
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Question Answer
Characteristics of nicotine includes (1)(1) nicotine is a colorless and mildly basic compound
Characteristics of nicotine includes (2)(2) It is highly pH dependents
Characteristics of nicotine includes (3)(3) at physiological pH, nicotine is readily absorbed
Characteristics of nicotine includes (4)(4) When ionized/altered (acidc conditioned), it is poorly or unabsorbed
Characteristics of nicotine includes (5)(5) it gets maximally absorbs basic medium (unionized/unaltered) and limitedly absorbed in acidic medium
Characteristics of nicotine includes (6)(6) beverages can alter pH of the environment (not of the nicotine), affect nicotine absorption. Hence, coffee helps w/ absorption
Nicotine is a colorless and mildly base, true or false?True, nicotine is a colorless and mildly basic compound.
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Question Answer
Nicotine absorption Skin and GI (1)(1) readily absorbed through intact skin
Nicotine absorption Skin and GI (2)(2) well absorbed in the small intestine but has low bioavailability (30%) due to first-pass hepatic metaboism
Nicotine absorption Lung (1)(1) in the lungs, Nicotine is “distilled” from burning tobacco and carried in tar droplets
Nicotine absorption Lung (2)(2) in the lungs, Nicotine is rapidly absorbed across respiratory epithelium
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Question Answer
Nicotine reaches the brain w/n ----- secs11 seconds
Nicotine absorption Buccal (Oral) Mucosa (1)(1) pH inside the mouth is 7.0 and less cigarette are absorbed while more nicotine are absorbed
Nicotine absorption Buccal (Oral) Mucosa (2)(2) Beverages can alter pH, affect absorption positively
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Question Answer
Nicotine Metabolism?It is Metabolized to Cotinine
Nicotine Excretion? (1)(1) Cotinine has half life of 19 hrs, excreted in urine and breast milk
Nicotine Excretion? (2)(2) Nicotine has a half life of 2hrs, excreted in urine and breast milk
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Question Answer
Nicotine Pharmacodynamics (1)(1) binds to receptors in the brain and other sites in the body; possesses stimulant and sedative properties
Nicotine Pharmacodynamics (2)(2) binds to CNS and create pleasure, arousal, enhanced vigilance, improved task performance, anxiety relief
Nicotine Pharmacodynamics (3)(3) Cardiovascular system, Increase HR/Cardiac output/blood pressure, Coronary vasoconstriction, Cutaneous vasoconstriction
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Question Answer
Nicotine effects? (1)(1) reduction of anxiety and tension, mood modulation and appetite suppression
Nicotine effects? (2)(2) Learning, memory enhancement and cognitive enhancement
Nicotine effects? (3)(3) Arousal, Pleasure, reward and appetite suppression
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Question Answer
What is addiction?Compulsive drug use, w/o medical purpose, in the face of negative consequences
Steps involve in Nicotine addiction?Nicotine stimulates dopamine release - pleasurable feelings - repeat administration - tolerance develops
True or false? Discontinuation of nicotine leads to withdraw symptomsTrue
Smokers has increased nicotine receptors in the prefrontal cortex, true or false?True
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Question Answer
Nicotine withdrawal effects (1)(1) Depression and anxiety
Nicotine withdrawal effects (2)(2) Restlessness and Insomnia
Nicotine withdrawal effects (3)(3) Irritability/Frustration/anger
Nicotine withdrawal effects (4)(4) Difficulty concentration
Nicotine withdrawal effects (5)(5) Increased appetite/weight gain
Nicotine withdrawal effects (6)(6) Decreased HR
Nicotine withdrawal effects (7)(7) Craving
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Question Answer
Tobacco users maintain a minimum serum nicotine concentration in order to (1)(1) Prevent withdrawal symptoms
Tobacco users maintain a minimum serum nicotine concentration in order to (2)(2) Maintain pleasure/arousal
Tobacco users maintain a minimum serum nicotine concentration in order to (3)(3) Modulate mood
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Question Answer
User self-titrate nicotine intake by (1)(1) Smoking/dipping more frequently
User self-titrate nicotine intake by (2)(2) Smoking more intensely
User self-titrate nicotine intake by (3)(3) Obstructing vents of low-nicotine brand cigarette
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Question Answer
What tool is used for assessing nicotine dependence?FIND: Fagerstom Test for Nicotine Dependence
Most withdrawal symptoms peak within ---- hrs to ------?24-48 hrs
Most withdrwal symptoms subside w/n ----- wks to ---- wks?2-4 wks
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Question Answer
Factors contributing to Tobacco use (Environment) (1)(1) Tobacco advertising
Factors contributing to Tobacco use (Environment) (2)(2) Conditioned Stimuli
Factors contributing to Tobacco use (Environment) (3)(3) Social Interactions
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Question Answer
Factors contributing to Tobacco use (Pharmacology) (1)(1) Alleviation of withdrawal symptoms
Factors contributing to Tobacco use (Pharmacology) (2)(2) Weight control
Factors contributing to Tobacco use (Pharmacology) (3)(3) Pleasure
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Factors contributing to Tobacco use (Physiology) (1)(1) Generic predisposition
Factors contributing to Tobacco use (Physiology) (2)(2) Coexisting medical conditions
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Question Answer
Drugs that may have decreased effects due to induction of CYP1A2(1) Coffee (2) Olanzapine (3) Fluvoxamine (4) Tacrine (5) Theophyline
What are the effects of smoking on oral contraceptives(1) Increased CV effects (2) it does not decrease the efficacy of oral contraceptives (3) Female age 35 and above has an elevated risk of CV
Clinically, significant interactions results NOT from nicotine but from the combustion products of tobacco smoke, true or false?True
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