Psych pharm notes - David

amprevel's version from 2017-01-22 19:48


MOA=mechanism of action, interactions, SE=side effects

Question Answer
Foods rich in SerotoninPineapple, turkey, sunflower seeds, tomatoes, pineapple, avocados, papaya
Common SE SSRIsNausea, diarrhea, sx disfunx, nervousness, somnolence, dry mouth
Serious SE SSRIsVertigo, ataxia, nausea, paresthesia, agitation
TCAs MOAReuptake inhibition serotonin, NE; some block histamine, AcH
D/C teaching TCAs1-week supply only, see provider for f/u and refill within 1 week
Common SE TCAsDry mouth, orthostatic hypoTN, blurred vision, constip, urinary ret., sedation
Serious SE TCAsCardiac toxicity, overdose
MAOIs MOAIncrease availability of NE, DA, and serotonin (5-HT)
MAOI avoid these foods d/t interaction:Tyramine or tryptophan - containing foods: aged cheese, red wine, soy sauce, salami, bananas, fermented sausages, liver, overripe fruits
Serious side effects MAOIsHypertensive crisis
Common SE MAOIsDry mouth, blurred vision, constipation, insomnia, hypoTN
Atypical antidepressants examplesRemeron (mirtazapine)
Wellbutrin (Bupropion)
Serzone (Nefazodone

Anti-anxiety agents (anxiolytics and minor tranq)

Question Answer
Anti anxiety agents indicationsanx, OCD, PTSD, ETOH w/d, muscle spasm, insomnia
Anti anxiety agents Pharmacological classificationsbenzodiazepines, barbituates, beta-blockers
Anti anxiety agents MOAdepression of limbic system, reticular formation of CNA. May increase GABA.
Common SE Anti anxiety agentssedation, confusion, tolerance
Major SEaddiction, dependence
Pharmacological classifications of anti anxiety agents, minor tranqsbenzodiazepines, barbiturates, beta-blockers
Short Acting anti anxiety agentsAtivan (lorazepam)
Serax (oxazepam)
Restoril (temazepam)
Xanax (alprazolam)
Prosom (estazolam)
Long ActingLibrium (chlordiazepoxide)
Valium (diazepam)
Dalmane (Flurazepam)
Klonopin (clonazepam)
Amobarbital (5-8hrs)
Secobarbital (1-1.5hrs)
Thiopentone (1-hour)
Methohexital (1-hour)

Mood stabilizers

Question Answer
Common side effects mood stabilizerssedation, weight gain, GI distress, tremor, thirstiness
Serious side effect mood stabilizerstoxicity, hepatotoxicity
Eskalith (Lithium) timeline for therapeutic effecteffect is gradual (5-7days for antimanic effect)
Therapeutic level Eskalith (Lithium)0.5-1.5mEq/L-this may take 3-weeks
Weekly or biweekly lab draw 12-hours after last dose
Acute mania level 0.6-1.2mEq/L
Maintenance level 0.4-1.0mEq/L
2-3days lab monitoring for therapeutic level
1-3months monitoring for maintenance level
Depakote (Valproic acid) blood level50-120mcg/ml
Tegretol (Carbamazepine) blood level monitoring how longMonitor blood levels weekly for the first 8 weeks
Common mood stabilizersEskalith (Lithium)
Lamictal (Lamotrigine)
Depakote (Valproic acid)
Tegretol (Carbamazepine)

CNS stimulants

Question Answer
Common side effects CNS stimulantsInsomnia, anorexia, jitteriness, headaches
Serious side effects CNS stimulantsTics, abuse, addiction, overdose, psychosis
Common CNS stimulantsAdderal (amphetamine)
Dexedrine (d-amphetamine)
Ritalin (methylphenidate)

Typical Antipsychotics

Typical antipsychotic agents were discovered in 1950s
First generation or conventional antipsychotic agents
They treat the psychotic symptoms such as hallucination and delusion

Question Answer
Antipsychotics indicationstreating psychosis such as hallucination, delusions, paranoia, agitation, nightmares, and altered mental status

Atypical Antipsychotics

Meds for EPS

Neuroleptic Malignant Syndrome (NMS) and Serotonin Syndrome (SES

Meds for Alzheimer's



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