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Polymer Drug Conjugates

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ndifranco94's version from 2015-11-05 21:02

Section

Question Answer
Why conjugate to polyer?increase blood circulation, sustained drug release, targeted drug delivery
Components in plymer-drug conjugatecleavable spacer, solubilizing group, targeting moiety
Why do you need spacer?polymer is too big, drug won't reach site otherwise
Characteristics of Polymer-Drug ConjugatesIncreased water solubility, targeted drug delivery, modify pharmacokinetics, EPR effect, site specific release, lower systemic toxicity
SpacerspH, enzyme, site
Polymersynthetic linear, natural, dendrimer
Targeting agentantibody, peptide, sugar, small organic
memorize