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Plasmacytoma

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arunmp's version from 2016-12-16 09:09

Section

Question Answer
Cell of origin in multiple myelomaMature B cells
MM constitutes --- of plasma cell tumors, while Solitary plasmacytoma (SP) constitutes ----- of plasma cell tumors90% & 10%
racial or sex predilectionBlack Men
2 forms of SP aresolitary bone plasmacytoma (SBP) and solitary extramedullary plasmacytoma (SEP)
SBP will progress to MM in ----- of pts at 10 yrs50%–80%
SEP will progress to MM in ----- of pts at 10 yrs10%–40%
most common site of SEPNASAL CAVITY AND PNS
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SBP VERSUS SEP
Question Answer
secretory TumorSBP
non secretorySEP
Lymphnode involvement10 -40 % of SEP; but rare in sbp
will progress to MM fastSBP
The Tx portal recommended in the primarymanagement of SEPis the extraosseous SP +primary draining LNs
Tx portal recommended in the primarymanagement of SbPtreat the entire involved bone with a 2–3-cm margin in RT Tx of SBP. In the spine,include 1vertebral body above and 2 vertebral bodiesbelow the lesion.
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