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Pharmakodynamics

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pod2ndyear's version from 2015-08-21 01:59

Pharmakodynamics

Question Answer
pharmakodynamic defeffect of drugs on the body
"drug target" or receptora protein that initiates the chain of biochemical event leading to the effects of the drug
what are some types of drug receptorsneruotransmitters, hormones and growth factors, autocouids, enzymes, transport proteins, carrier molecules, ion channels, structural proteins, nuc acids
agonistsa drug that binds to and ACTIVATES a receptor. initias a response
antagonistdrugs that bind to receptors or other drugs that INHIBIT. no response
what are the 4 major signaling mechanismsTransmemebrane, ligan ion gated, intracelluar, second messenger system
what are some drug actions not mediated by receptorschelating agents-for heavy metals, antacids, chemical neutralization-like heprin to stop bleeding, osmotic diuretics-like mannitol
occupation theorydrug + same amount of receptor equals a proportional effect. (doesnt apply very well
square root theorydrug + small amount of receptor equals a max effect of drug (more correct theory) becuase different drugs have different effects they are not all equal
Efficacy vs potencyis the ability of a drug to have a maximal effect. potency is related to the amount(doses) of drug needed to produce an effect. (size of the pill)
full agonistdrug capible of generating 100% max response
partial agonistdrug that generates a less than 100% max response. (there is a balance between being active inactive
inverse agonista drug that stabalizes an active receptor in the inactive conformation (lack of action or even the opposite action
If drug A and C affect the target the same this meansthey have the same efficacy
if more of C is needed than a to reach the same target this meansA is more potent
Therapeutic Indexknow what dose to take to reach wanted target vs how much dose of same drug could kill you
What are the types of drug antagnismcompetative-overcomed by adding more agonist, noncompetative-cannot be overcomed by adding more agonist, physiological-like an epipen for anaphylactic shock, chemical
memorize