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Pharmacology

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navyy's version from 2017-09-10 17:31

Drug endings

EndingCategory
-adine2nd generation H1 blocker
-afilErectile dysfunction
-aneInhalational general anethesthetic
-azepamBenzodiazepine (1)
-azinePhenothiazine (neuroleptic, antiemetic)
-azoleAntifungal
-barbitalBarbituate
-caineLocal anesthetic
-cillinPenicillin
-cyclineAntibiotic, protein synthesis inhibitor
-etineSSRI
-idineH2 blocker
-ipramineTCA (1)
-navirProtease inhibitor
-ololBeta blocker
-operidolButyrophenone (neuroleptic)
-oxinCardiac glycoside
-phyllineMethylxanthine (e.g. Theophylline)
-prilACE inhibitor
-terolBeta 2 agonist
-tidineH2 antagonist
-triptan5-HT 1B/1D agonists (migraine)
-triptylineTCA (2)
-tropinPituitary hormone
-zolamBenzodiazepine (2)
-zosinalpha-1 antagonist
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P450 Interactions

Queen barb Steals Phen-phen and Refuses Greasy Carbs Chronically
Inhibit yourself from dreaking a KEG because it makes you Acutely SICK
DrugInduction/Inhibition
QuinidineInducer
BarbituateInducer
St. John's WortInducer
PhenytoinInducer
RifampinInducer
GriseofulvinInducer
CarbamezepineInducer
Chronic alcohol useInducer
SulfonamidesInhibitor
IsoniazidInhibitor
CimetidineInhibitor
KetoconazoleInhibitor
ErythromycinInhibitor
Grapefruit juiceInhibitor
Acute alcohol useInhibitor
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Antidotes

ToxinAntidote/Treatment
AcetaminophenN-acetylcysteine
SalicylatesNaHCO3 (urine alkalinization)
AmphetaminesNH4Cl (urine acidification)
Anticholinesterases, organophosphatesAtropine, pralidoxime
Antimuscarinic, anticholinergic agentsPhysostigmine salicylate
Beta blockersGlucagon
DigitalisStop dig, normalize K+, anti-dig Fab, Mg2+
IronDeferoxamine
LeadCaEDTA, dimercaprol, succimer (kids), penicillamine
Mercury, arsenic, goldDimercaprol (BAL), succimer
Copper, arsenic, goldPenicillamine
CyanideNitrite, hydroxocobalamin, thiosulfate
MethemoglobinMethylene blue, vitamin C
Carbon monoxide100% oxygen, Hyperbaric oxygen
Methanol, ethylene glycolEthanol, dialysis, fomepizole
OpioidsNaloxone/Naltrexone
BenzodiazepinesFlumazenil
TCAsNaHCO3 (serum alkalinization)
HeparinProtamine
WarfarinVitamin K, fresh frozen plasma
tPA, streptokinaseAminocaproic acid
TheophyllineBeta blocker
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Signature Drug Toxicities

ToxicityDrug
AgranulocytosisClozapine, Chloramphenicol
Aplastic AnemiaChloramphenicol, NSAIDs, Benzene
Atropine-like Side EffectsTricyclics
CardiotoxicityAnti-Arrythmics, Local Anesthetics (Prilocaine least but causes Methemoglobinemia) , Anti-cancer (Doxorubicin)
Cartilage Damage in Children, TendinitisFluoroquinolones (Ciprofloxacin & Norfloxacin)
CinchonismQuinidine
Dry CoughACE Inhibitors, ARBs
Nephrogenic Diabetes InsipidusLithium (Txt w/ Amiloride)
Disulfiram-like EffectMetronidazole, Sulfonylureas (1st generation), Cephalosporins
Extrapyramidal Side EffectsAntipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Fanconi’s SyndromeExpired tetracycline
Fatal Hepatotoxicity (necrosis)Valproic Acid, Halothane, Acetaminophen
Gingival Hyperplasia, HirsutismPhenytoin
Gray Baby SyndromeChloramphenicol
GynecomastiaCimetidine, Azoles, Spironolactone, Digitalis, Haloperidol
Hemolytic Anemia in G6PD-deficiencySulfonamides, Isoniazid, Aspirin, Ibuprofen (NSAID), Primaquine
HepatitisIsoniazid
Hot Flashes, FlushingNiacin, Tamoxifen, CCB, Bronchodilators, Morphine
Induce CP450Barbiturates – Phenobarbital, Phenytoin, Carbamazepine, Rifampin
Inhibit CP450Cimetidine, Ketoconazole
Interstitial NephritisMethicillin, NSAIDs (except Aspirin), Furosemide, Sulfonamides
Monday DiseaseNitroglycerin , Industrial exposure → tolerance during week → loss of tolerance during weekend → headache, dizziness upon re-exposure
Orange Body FluidsRifampin
OsteoporosisHeparin, Corticosteroids
Positive Coombs’ TestMethyldopa
Pulmonary FibrosisBleomycin, Amiodarone
Red Man SyndromeVancomycin
Severe HTN with TyramineMAOIs
SLE-like SyndromeProcainamide, Hydralazine, INH
Tardive DyskinesiaAntipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Clozapine=only antipsychotic to not give you tardive dyskinesia
TinnitusAspirin, Quinidine
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Signaling pathways

Endocrine
HormonePathway
FSHcAMP
LHcAMP
ACTHcAMP
TSHcAMP
CRHcAMP
hCGcAMP
ADH (V2)cAMP
MSHcAMP
PTHcAMP
CalcitonincAMP
GlucagoncAMP
ANPcGMP
NO (EDRF)cGMP
GnRHIP3
GHRHIP3
OxytocinIP3
ADH (V1)IP3
TRHIP3
GlucocorticoidSteroid receptor
EstrogenSteroid receptor
ProgesteroneSteroid receptor
TestosteroneSteroid receptor
AldosteroneSteroid receptor
Vitamin DSteroid receptor
T3/T4Steroid receptor
InsulinTyrosine Kinase
IGF-1Tyrosine Kinase
FGFTyrosine Kinase
PDGFTyrosine Kinase
ProlactinTyrosine Kinase
GHTyrosine Kinase
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G-protein-linked 2nd messengers
ReceptorG-protein classDownstream pathwayLocation
α1GqPhospholipase C --> PIP2 --> IP3 + DAG --> ↑ Ca, activated Protein Kinase CVascular smooth muscles, intestines, bladder, pupil
α2GiAdenylate cyclase (activation: --> ↓ cAMP --> ↓ Protein Kinase ASympathetic nerve (negative feedback)
β1GsAdenylate cyclase (inhibition) --> ↑ cAMP --> activated Protein Kinase AHeart, JGA, adiopocytes
β2GsAdenylate cyclase (inhibition) --> ↑ cAMP --> activated Protein Kinase ABlood vessels, bronchioles, heart, beta cells, uterus
M1GqPhospholipase C --> PIP2 --> IP3 + DAG --> ↑ Ca, activated Protein Kinase CCNS, enteric nervous system
M2GiAdenylate cyclase (activation: --> ↓ cAMP --> ↓ Protein Kinase AHeart
M3GqPhospholipase C --> PIP2 --> IP3 + DAG --> ↑ Ca, activated Protein Kinase CExocrine glands, Gut (specifically, stomach --> H+ release)
D1GsAdenylate cyclase (inhibition) --> ↑ cAMP --> activated Protein Kinase ARenal vascular smooth muscle
D2GiAdenylate cyclase (activation: --> ↓ cAMP --> ↓ Protein Kinase ABrain
H1GqPhospholipase C --> PIP2 --> IP3 + DAG --> ↑ Ca, activated Protein Kinase CBronchioles
H2GsAdenylate cyclase (inhibition) --> ↑ cAMP --> activated Protein Kinase AStomach
V1GqPhospholipase C --> PIP2 --> IP3 + DAG --> ↑ Ca, activated Protein Kinase CVascular smooth muscle
V2GsAdenylate cyclase (inhibition) --> ↑ cAMP --> activated Protein Kinase ACollecting tubules
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Treatments for psychiatric conditions

ConditionDrug
Alcohol withdrawalBenzodiazepines
BulimiaSSRIs
AnxietyBenzodiazepines, Buspirone, SSRis
ADHDMethylphenidate, Dexedrine (amphetamines)
Atypical depressionMAOis
Bipolar disorderLithium, valproic acid, carbamazepine
DepressionSSRIs, SNRIs, TCAs
Depression with insomniaMirtazapine
OCDSSRis, Clomipramine
Panic DisorderSSRIs, TCAs, Benzodiazepines
PTSDSSRIs
SchizophreniaAntipsychotics
Tourette'sHaloperidol
Social phobiasSSRIs
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